{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:22:01Z","timestamp":1767856921436,"version":"3.49.0"},"reference-count":80,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T00:00:00Z","timestamp":1691193600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAPES\/RENORBIO\/PROAP"},{"name":"INCT-Bioanal\u00edtica"},{"name":"FAPEAL\/PPSUS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2023,8,5]]},"abstract":"<jats:p>Ulcerative colitis (UC) is a chronic and recurrent inflammatory bowel disease (IBD) characterized by continuous inflammation in the colonic mucosa. Extraintestinal manifestations (EIM) occur due to the disruption of the intestinal barrier and increased permeability caused by redox imbalance, dysbiosis, and inflammation originating from the intestine and contribute to morbidity and mortality. The aim of this study is to investigate the effects of oral N-acetylcysteine (NAC) on colonic, hepatic, and renal tissues in mice with colitis induced by dextran sulfate sodium (DSS). Male Swiss mice received NAC (150\u2009mg\/kg\/day) in the drinking water for 30 days before and during (DSS 5% v\/v; for 7 days) colitis induction. On the 38th day, colon, liver, and kidney were collected and adequately prepared for the analysis of oxidative stress (superoxide dismutase (SOD), catalase (CAT), glutathione reduced (GSH), glutathione oxidized (GSSG), malondialdehyde (MDA), and hydrogen peroxide (H2O2)) and inflammatory biomarkers (myeloperoxidase (MPO) \u2013, tumor necrosis factor alpha \u2013 (TNF-\u03b1, and interleukin-10 (IL-10)). In colon, NAC protected the histological architecture. However, NAC did not level up SOD, in contrast, it increased MDA and pro-inflammatory effect (increased of TNF-\u03b1 and decreased of IL-10). In liver, colitis caused both oxidative (MDA, SOD, and GSH) and inflammatory damage (IL-10). NAC was able only to increase GSH and GSH\/GSSG ratio. Kidney was not affected by colitis; however, NAC despite increasing CAT, GSH, and GSH\/GSSG ratio promoted lipid peroxidation (increased MDA) and pro-inflammatory action (decreased IL-10). Despite some beneficial antioxidant effects of NAC, the negative outcomes concerning irreversible oxidative and inflammatory damage in the colon, liver, and kidney confirm the nonsafety of the prophylactic use of this antioxidant in models of induced colitis, suggesting that additional studies are needed, and its use in humans not yet recommended for the therapeutic routine of this disease.<\/jats:p>","DOI":"10.1155\/2023\/8811463","type":"journal-article","created":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T17:05:07Z","timestamp":1691255107000},"page":"1-17","source":"Crossref","is-referenced-by-count":6,"title":["Extraintestinal Manifestations in Induced Colitis: Controversial Effects of N-Acetylcysteine on Colon, Liver, and Kidney"],"prefix":"10.1155","volume":"2023","author":[{"given":"Amylly Sanuelly","family":"da Paz Martins","sequence":"first","affiliation":[{"name":"Doctoral Program of the Northeast Biotechnology Network, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00edvia Queiroz","family":"de Andrade","sequence":"additional","affiliation":[{"name":"College of Nutrition, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando Roberto Pimentel","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn C\u00f4sallin Melquiades","family":"da Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biotechnology, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"da Silva Gomes","sequence":"additional","affiliation":[{"name":"College of Nutrition, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia Oliveira Fonseca","family":"Goulart","sequence":"additional","affiliation":[{"name":"Doctoral Program of the Northeast Biotechnology Network, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"},{"name":"Institute of Chemistry and Biotechnology, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"},{"name":"Institute of Biological and Health Sciences, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-0193","authenticated-orcid":true,"given":"Fabiana Andr\u00e9a","family":"Moura","sequence":"additional","affiliation":[{"name":"College of Nutrition, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"},{"name":"College of Medicine, Federal University of Alagoas, Macei\u00f3 57072-970, Alagoas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2017.07.001"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.09.013"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.173753"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180904115633"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9622-2"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.32604\/biocell.2021.014332"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2017160121"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy191"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv213"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060967"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161226225"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.9b00152"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01061422"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107916"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2851"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2020.08.010"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1099-081X"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(80)90340-3"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-867-2_20"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(02)00387-1"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12506462"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i13.3507"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8030343"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-021-00327-y"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1080\/15376510701533996"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/718617"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO01228G"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095332"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116199"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00640-2"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.07.003"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2019.103213"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-0985-1"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7918261"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1055\/a-1389-5499"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.10.006"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.06.014"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4047362"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9949453"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2018.1468564"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.04.016"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.05.138"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1039\/C1MB05315A"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.08.052"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087229"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309598"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000155"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780077"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(01)00094-5"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.6.993"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1177\/147323000503300207"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1155\/MI.2005.390"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.206.131"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04890.x"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01454-06"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0563-9"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2012.734859"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.05.009"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S288412"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108814"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2851"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.12.005"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109683"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023967"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.01.004"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2019.4539"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.865273"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6020247"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.02.086"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04660513"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v89i9-S.7908"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00702.2012"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00319.2013"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2018.05.003"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12950"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2016.1273365"},{"issue":"8","key":"80","first-page":"1938","article-title":"NAC attenuates adriamycin-induced nephrotic syndrome in rats through regulating TLR4 signaling pathway","volume":"21","author":"H. Yao","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2023\/8811463.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2023\/8811463.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2023\/8811463.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T17:05:27Z","timestamp":1691255127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2023\/8811463\/"}},"subtitle":[],"editor":[{"given":"Fatma M.","family":"El-Demerdash","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,8,5]]},"references-count":80,"alternative-id":["8811463","8811463"],"URL":"https:\/\/doi.org\/10.1155\/2023\/8811463","relation":{},"ISSN":["1942-0994","1942-0900"],"issn-type":[{"value":"1942-0994","type":"electronic"},{"value":"1942-0900","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,5]]}}}