{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:50:14Z","timestamp":1771462214441,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:p>Background. Primary central nervous system lymphoma (PCNSL) is a rare, aggressive form of non-Hodgkin lymphoma contained in the brain and the spinal cord as well as the meninges, cranial nerves, eyes, and cerebrospinal fluid (CSF). Due to its variable presentation and lack of associated B-symptoms, it is quite challenging to diagnose PCNSL, if there is not a high level of suspicion. Methods. This is a retrospective case series examining 13 human immunodeficiency virus- (HIV-) negative patients with PCNSL and DLBCL type, with a median age of 75 years old. Results. The most common presenting symptom was altered mental status. The frontal lobes, basal ganglia, cerebellum, and corpus callosum were most affected. Prior to brain biopsy, 4\/13 patients were on steroids, which did not affect biopsy results and the average time to diagnosis was 1 month. 9\/13 patients who did not receive steroids had an average time to diagnosis of less than 1 month. Conclusion. Although steroid administration did not appear to diminish the yield of the biopsy, it is a best practice to withhold steroids prior to biopsy to decrease the time to diagnose PCNSL.<\/jats:p>","DOI":"10.1155\/2023\/8815502","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:05:07Z","timestamp":1684285507000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["Central Nervous System Lymphoma: The Great Mimicker\u2014A Single-Institution Retrospective Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9459-7773","authenticated-orcid":true,"given":"Danielle A.","family":"Bazer","sequence":"first","affiliation":[{"name":"Department of Neurology, Stony Brook University Hospital, Health Sciences Tower T12\/020, Stony Brook, New York 11794-8121, USA"},{"name":"Department of Neurology, Johns Hopkins University, 201 N Broadway, 9th Floor Mailbox #3, Baltimore, MD 21287, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Zabrocka","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Stony Brook University Hospital, Level 2, Stony Brook, New York 11794-8121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Koroneos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stony Brook University Hospital, Health Sciences Tower T12\/020, Stony Brook, New York 11794-8121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Kowalska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stony Brook University Hospital, Health Sciences Tower T12\/020, Stony Brook, New York 11794-8121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.7602"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-014-0217-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1212\/01.CON.0000464175.96311.0a"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.8819"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23551"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.565"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.03.019"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy192"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-021-01116-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008377"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa215.526"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-020-03547-z"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.3"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30118-1"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112392"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2023\/8815502.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2023\/8815502.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2023\/8815502.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:05:08Z","timestamp":1684285508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crionm\/2023\/8815502\/"}},"subtitle":[],"editor":[{"given":"Ossama W.","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":15,"alternative-id":["8815502","8815502"],"URL":"https:\/\/doi.org\/10.1155\/2023\/8815502","relation":{},"ISSN":["2090-6714","2090-6706"],"issn-type":[{"value":"2090-6714","type":"electronic"},{"value":"2090-6706","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}