{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:50:09Z","timestamp":1788385809583,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015310","name":"Natural Science Foundation of Xinjiang","doi-asserted-by":"publisher","award":["2020D01C250"],"award-info":[{"award-number":["2020D01C250"]}],"id":[{"id":"10.13039\/501100015310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015310","name":"Natural Science Foundation of Xinjiang","doi-asserted-by":"publisher","award":["82060401"],"award-info":[{"award-number":["82060401"]}],"id":[{"id":"10.13039\/501100015310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020D01C250"],"award-info":[{"award-number":["2020D01C250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060401"],"award-info":[{"award-number":["82060401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tissue Engineering and Regenerative Medicine"],"published-print":{"date-parts":[[2023,6,14]]},"abstract":"<jats:p>Distraction osteogenesis (DO) is a widely employed method for the treatment of limb discrepancies and deformity correction. This study aimed at observing the histomorphological and ultrastructural changes of peripheral nerves around the distraction area during DO and investigating the self-repair mechanism of peripheral nerves in a rat DO model. Sixty rats underwent right femoral DO surgery and were randomly separated into six groups: Control (latency, no distraction, n\u2009=\u200910), Group 0-week (after distraction, n\u2009=\u200910), Group 2-week (n\u2009=\u200910), Group 4-week (n\u2009=\u200910), Group 6-week (n\u2009=\u200910), and Group 8-week (n\u2009=\u200910) at consolidation phase. The right femur of rats in Group 0-week, Group 2-week, Group 4-week, Group 6-week, and Group 8-week was subjected to continuous osteogenesis distraction at a rate of 0.5\u2009mm\/day for 10\u2009days. Motor nerve conduction velocity (MNCV) of the sciatic nerve, sciatic function index (SFI), histological analyses, and transmission electron microscopy were conducted to evaluate nerve function. The MNCV and SFI of Group 0-week, Group 2-week, Group 4-week, and Group 6-week were significantly lower than the Control (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). No statistical differences were found between the Control and Group 8-week in terms of MNCV and SFI (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&gt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Injuries to nerve fibres and nodes of Ranvier were observed in the Group 0-week, whereas the nerve fibres returned to the normal arrangement in the Group 8-week and oedema of myelin disappeared, with the continuity of axons and lamellar structure of myelin being restored. Femoral DO in rats with a rate of 0.5\u2009mm\/day may cause sciatic neurapraxia, which can be self-repaired after 8\u2009weeks of consolidation. The paraneurium around the sciatic nerve enables it to glide during the distraction phase to reduce the occurrence of injurious changes.<\/jats:p>","DOI":"10.1155\/2023\/8818561","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T21:20:08Z","timestamp":1686777608000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Distraction Osteogenesis on Peripheral Nerve Regeneration in Rats: A Preliminary Study In Vivo"],"prefix":"10.1155","volume":"2023","author":[{"given":"Kai","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Uygur Medical College, Xinjiang Medical University, Urumqi, Xinjiang 830011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-2303","authenticated-orcid":true,"given":"Aihemaitijiang","family":"Yusufu","sequence":"additional","affiliation":[{"name":"Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-6116","authenticated-orcid":true,"given":"Yanshi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-021-05011-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s10195-019-0541-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.810723"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/term.2534"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.810676"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.31883"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4176-12.2013"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.226426"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s0753-9053(05)80485-5"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600236"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1994_031_0473_eacewd_2.3.co_2"},{"key":"12","first-page":"49","article-title":"The principles of the Ilizarov method. 1988","volume":"56","author":"G. 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