{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:01:04Z","timestamp":1785369664045,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2023,4,24]]},"abstract":"<jats:p>In the past years, the knowledge of eosinophils playing a primary pathophysiologic role in several associated conditions has led to the development of biologics targeting therapies aiming at normalizing the immune response, reducing chronic inflammation, and preventing tissue damage. To better illustrate the potential relationship between different eosinophilic immune dysfunctions and the effects of biological therapies in this scenario, here, we present a case of a 63-year-old male first referred to our department in 2018 with a diagnosis of asthma, polyposis, and rhinosinusitis and presenting a suspicion of nonsteroidal anti-inflammatory drugs\u2019 allergy. He also had a past medical history of eosinophilic gastroenteritis\/duodenitis (eosinophilia counts &gt;50\u2009cells\/high-power field HPF). The use of multiple courses of corticosteroid therapy failed to completely control these conditions. In October 2019, after starting benralizumab (an antibody directed against the alpha chain of the IL-5 cytokine receptor) as add-on treatment for severe eosinophilic asthma, important clinical improvements were reported both on the respiratory (no asthma exacerbations) and gastrointestinal systems (eosinophilia count 0\u2009cells\/HPF). Patients\u2019 quality of life also increased. Since June 2020, systemic corticosteroid therapy was reduced without worsening of gastrointestinal symptoms or eosinophilic inflammation. This case warns of the importance of early recognition and appropriate individualized treatment of eosinophilic immune dysfunctions and suggests the conduction of further larger studies on the use of benralizumab in gastrointestinal syndromes aiming at better understanding its relying mechanisms of action in the intestinal mucosa.<\/jats:p>","DOI":"10.1155\/2023\/8832242","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T23:20:05Z","timestamp":1682378405000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["The Role of Benralizumab in Eosinophilic Immune Dysfunctions: A Case Report-Based Literature Review"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-4252","authenticated-orcid":true,"given":"Margarida","family":"Gomes","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Imunoalergologia, Hospital de Santa Maria, Centro Hospitalar e Universit\u00e1rio Lisboa Norte, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mendes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunoalergologia, Hospital de Santa Maria, Centro Hospitalar e Universit\u00e1rio Lisboa Norte, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Gastroenterologia, Hospital Professor Doutor Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Branco","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Gastroenterologia, Hospital Professor Doutor Fernando Fonseca, EPE, Amadora, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-8608","authenticated-orcid":true,"given":"Fernanda S.","family":"Tonin","sequence":"additional","affiliation":[{"name":"H & TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Sa\u00fade, Instituto Polit\u00e9cnico de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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