{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:34:40Z","timestamp":1792974880564,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:00:00Z","timestamp":1699920000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170786"],"award-info":[{"award-number":["82170786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670688"],"award-info":[{"award-number":["81670688"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800666"],"award-info":[{"award-number":["81800666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205273"],"award-info":[{"award-number":["82205273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100816"],"award-info":[{"award-number":["82100816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023A1515010422"],"award-info":[{"award-number":["2023A1515010422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021A1515010354"],"award-info":[{"award-number":["2021A1515010354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022A1515010250"],"award-info":[{"award-number":["2022A1515010250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["202103000035"],"award-info":[{"award-number":["202103000035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023A03J0201"],"award-info":[{"award-number":["2023A03J0201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20231063"],"award-info":[{"award-number":["20231063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022GZRPYQN07"],"award-info":[{"award-number":["2022GZRPYQN07"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["82170786"],"award-info":[{"award-number":["82170786"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["81670688"],"award-info":[{"award-number":["81670688"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["81800666"],"award-info":[{"award-number":["81800666"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["82205273"],"award-info":[{"award-number":["82205273"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["82100816"],"award-info":[{"award-number":["82100816"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010422"],"award-info":[{"award-number":["2023A1515010422"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010354"],"award-info":[{"award-number":["2021A1515010354"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010250"],"award-info":[{"award-number":["2022A1515010250"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["202103000035"],"award-info":[{"award-number":["202103000035"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A03J0201"],"award-info":[{"award-number":["2023A03J0201"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["20231063"],"award-info":[{"award-number":["20231063"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022GZRPYQN07"],"award-info":[{"award-number":["2022GZRPYQN07"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["82170786"],"award-info":[{"award-number":["82170786"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["81670688"],"award-info":[{"award-number":["81670688"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["81800666"],"award-info":[{"award-number":["81800666"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["82205273"],"award-info":[{"award-number":["82205273"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["82100816"],"award-info":[{"award-number":["82100816"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023A1515010422"],"award-info":[{"award-number":["2023A1515010422"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2021A1515010354"],"award-info":[{"award-number":["2021A1515010354"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2022A1515010250"],"award-info":[{"award-number":["2022A1515010250"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202103000035"],"award-info":[{"award-number":["202103000035"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023A03J0201"],"award-info":[{"award-number":["2023A03J0201"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["20231063"],"award-info":[{"award-number":["20231063"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2022GZRPYQN07"],"award-info":[{"award-number":["2022GZRPYQN07"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["82170786"],"award-info":[{"award-number":["82170786"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["81670688"],"award-info":[{"award-number":["81670688"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["81800666"],"award-info":[{"award-number":["81800666"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["82205273"],"award-info":[{"award-number":["82205273"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["82100816"],"award-info":[{"award-number":["82100816"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A1515010422"],"award-info":[{"award-number":["2023A1515010422"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2021A1515010354"],"award-info":[{"award-number":["2021A1515010354"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2022A1515010250"],"award-info":[{"award-number":["2022A1515010250"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202103000035"],"award-info":[{"award-number":["202103000035"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A03J0201"],"award-info":[{"award-number":["2023A03J0201"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["20231063"],"award-info":[{"award-number":["20231063"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2022GZRPYQN07"],"award-info":[{"award-number":["2022GZRPYQN07"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["82170786"],"award-info":[{"award-number":["82170786"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["81670688"],"award-info":[{"award-number":["81670688"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["81800666"],"award-info":[{"award-number":["81800666"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["82205273"],"award-info":[{"award-number":["82205273"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["82100816"],"award-info":[{"award-number":["82100816"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010422"],"award-info":[{"award-number":["2023A1515010422"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010354"],"award-info":[{"award-number":["2021A1515010354"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010250"],"award-info":[{"award-number":["2022A1515010250"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["202103000035"],"award-info":[{"award-number":["202103000035"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["2023A03J0201"],"award-info":[{"award-number":["2023A03J0201"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20231063"],"award-info":[{"award-number":["20231063"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["2022GZRPYQN07"],"award-info":[{"award-number":["2022GZRPYQN07"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["82170786"],"award-info":[{"award-number":["82170786"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["81670688"],"award-info":[{"award-number":["81670688"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["81800666"],"award-info":[{"award-number":["81800666"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["82205273"],"award-info":[{"award-number":["82205273"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["82100816"],"award-info":[{"award-number":["82100816"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2023A1515010422"],"award-info":[{"award-number":["2023A1515010422"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2021A1515010354"],"award-info":[{"award-number":["2021A1515010354"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2022A1515010250"],"award-info":[{"award-number":["2022A1515010250"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["202103000035"],"award-info":[{"award-number":["202103000035"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2023A03J0201"],"award-info":[{"award-number":["2023A03J0201"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["20231063"],"award-info":[{"award-number":["20231063"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["2022GZRPYQN07"],"award-info":[{"award-number":["2022GZRPYQN07"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stem Cells International"],"published-print":{"date-parts":[[2023,11,14]]},"abstract":"<jats:p>Interstitial cystitis\/bladder pain syndrome (IC\/BPS) seriously reduces the patient\u2019s quality of life, yet current therapies only provide partial relief. In the spinal dorsal horn (SDH), neuroinflammation plays a pivotal role in the development of IC. Injection of human umbilical cord mesenchymal stem cells (hUMSCs) to reduce inflammation is an effective strategy, and heme oxygenase-1 (HO-1) exhibits anti-nociceptive effect in neuroinflammatory pain. This study aimed to test the therapeutic effects of hUMSCs overexpressing HO-1 on cyclophosphamide-induced cystitis rat model. Cystitis rats were transplanted with altered cells and then assessed for 3 weeks. A series of behavioral measurements would be trial including suprapubic mechanical allodynia, depressive-like behaviors, micturition frequency, and short-term memory function. Additionally, western blot, immunofluorescence staining, and ELISA kit test for anti-inflammation effect. HUMSCs were capable of being transduced to overexpress HO-1. Injection of hUMSCs overexpressing HO-1 was more effective than hUMSCs alone in alleviating behavioral symptoms in rats. Furthermore, hUMSCs overexpressing HO-1 inhibited the activation of glial and TLR4\/p65\/NLRP3 pathway, decreased the levels of pro-inflammatory cytokines in the SDH region. Surprisingly, it markedly increased anti-inflammatory cytokine IL-10, reduced MDA content, and protected GSH concentrations in local environment. Our results suggest that injecting hUMSCs overexpressing HO-1 intrathecally can significantly promote functional outcomes in cystitis rats by reducing neuroinflammation, at least, partly through downregulating TLR4\/p65\/NLRP3 signaling pathway in the SDH region. This cell therapy affords a new strategy for IC\/BPS treatment.<\/jats:p>","DOI":"10.1155\/2023\/8887091","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T16:35:16Z","timestamp":1699979716000},"page":"1-14","source":"Crossref","is-referenced-by-count":2,"title":["Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8029-6398","authenticated-orcid":true,"given":"Qiongqiong","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhentao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Center, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8464-2255","authenticated-orcid":true,"given":"Hailun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8315-0404","authenticated-orcid":true,"given":"Bolong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-6691","authenticated-orcid":true,"given":"Xiangfu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, 2693 Kaichuang Road, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000165452.39125.98"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.086"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14234"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.01.242"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23421"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2147\/RRU.S238746"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916674479"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24005"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-1704-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02445-7"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2015.55"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.043"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1124\/pr.107.07104"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.10.009"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704014"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-011-0090-8"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0816-1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.04.012"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12712"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2019-0002"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2019.04.002"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1383-2"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2017.18.3.377"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-02178-4"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8537541"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-018-0540-0"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0519-3"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2018.054"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16851"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0555-9"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2021.101144"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.072"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0157-8"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147754"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.09.101"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916646784"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3376-06.2006"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-019-0317-6"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800958"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6403861"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.05.023"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940185"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.079"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.096"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000109414.78907.F9"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00244"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.08.001"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.7150\/thno.31711"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-1747929\/v1"}],"container-title":["Stem Cells International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2023\/8887091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2023\/8887091.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/sci\/2023\/8887091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T16:35:23Z","timestamp":1699979723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/sci\/2023\/8887091\/"}},"subtitle":[],"editor":[{"given":"Patricia","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":51,"alternative-id":["8887091","8887091"],"URL":"https:\/\/doi.org\/10.1155\/2023\/8887091","relation":{},"ISSN":["1687-9678","1687-966X"],"issn-type":[{"value":"1687-9678","type":"electronic"},{"value":"1687-966X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,14]]}}}