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This case describes a 41-year-old male with a history of schizoaffective disorder and polysubstance use who was admitted to an inpatient psychiatry unit for acute manic and psychotic symptoms in the setting of absconding from his residential home and noncompliance with prescribed psychiatric medications. During his inpatient psychiatric hospitalization, he experienced DRESS (drug reaction with eosinophilia and systemic symptoms) with valproate, nephrogenic diabetes insipidus with lithium, potential neuroleptic malignant syndrome with risperidone, and orthostasis\/tachycardia with clozapine. He ultimately achieved stabilization of manic and psychotic symptoms with loxapine without experiencing adverse events. This report highlights the potential utility of loxapine in individuals with schizoaffective disorder intolerant to standard mood-stabilizing and antipsychotic medications.<\/jats:p>","DOI":"10.1155\/2023\/8887553","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T17:50:06Z","timestamp":1686419406000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["Loxapine in the Treatment of Manic and Psychotic Symptoms in an Individual Intolerant to Multiple Mood-Stabilizing and Antipsychotic Medications"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-5806","authenticated-orcid":true,"given":"David S.","family":"Im","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Michigan Medical School, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0589-1258","authenticated-orcid":true,"given":"Marina","family":"Capitanov","sequence":"additional","affiliation":[{"name":"University of Michigan Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-2694","authenticated-orcid":true,"given":"Amy M.","family":"VandenBerg","sequence":"additional","affiliation":[{"name":"University of Michigan College of Pharmacy, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.177901"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181db2684"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.03.006"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/01.NURSE.0000365921.24254.4a"},{"issue":"1","key":"5","first-page":"63","article-title":"Lithium-induced nephrogenic diabetes insipidus","volume":"30","author":"N. 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