{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:13:42Z","timestamp":1771647222259,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2023,7,3]]},"abstract":"<jats:p>Background. Intraoperative radiotherapy (IORT) is a novel promising technology that may replace external beam radiation therapy (EBRT) as boost for patients receiving breast-conserving surgery. To better evaluate the efficacy of IORT using low-kilovoltage (low-kV) X-rays as boost, we presented this meta-analysis according to the PRISMA checklist. Methods. Studies reported survival outcomes of intraoperative radiation using low-kilovoltage X-rays system (Intrabeam\u00ae, Carl Zeiss Meditec, Dublin, CA, USA) as boost were identified through electronic bibliographic database: PUBMED. The meta-analysis module in Stata (16.0) is used to pool the studies. A Poisson regression model is used to predict a 5-year local recurrence rate. Results. Twelve studies including 3006 cases were included in the final analysis, with a median follow-up of 55\u2009months weighted by sample size. The pooled local recurrence rate is 0.39% per person-year (95% CI: 0.15%\u20130.71%), with a low degree of heterogeneity (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:msup>\n                           <a:mrow>\n                              <a:mi>I<\/a:mi>\n                           <\/a:mrow>\n                           <a:mrow>\n                              <a:mn>2<\/a:mn>\n                           <\/a:mrow>\n                        <\/a:msup>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009=\u20090%). The predicted 5-year local recurrence rate was 3.45%. No difference in pooled local recurrence rate was found between non-neoadjuvant patients studies and neoadjuvant patients studies (0.41% per person-year vs. 0.58% per person-year, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.580<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Conclusions. This study shows that low-kV IORT is an effective method as boost in breast cancer patients, with a low pooled local recurrence rate and low predicted 5-year local recurrence rate. Besides, no difference in the local recurrence rate was found between non-neoadjuvant patients studies and neoadjuvant patients studies. Low-kV IORT boost may be a promising alternative to EBRT boost in the future, which is being tested in the ongoing TARGIT-B trial.<\/jats:p>","DOI":"10.1155\/2023\/9035266","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T23:05:18Z","timestamp":1688425518000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["The Efficacy of Low-Kilovoltage X-Rays Intraoperative Radiation as Boost for Breast Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2023","author":[{"given":"Yuanjian","family":"Fan","sequence":"first","affiliation":[{"name":"Center of Vascular-Thyroid-Breast Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiwan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Center of Vascular-Thyroid-Breast Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-2375","authenticated-orcid":true,"given":"Yunjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Vascular-Thyroid-Breast Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Shao","sequence":"additional","affiliation":[{"name":"Center of Vascular-Thyroid-Breast Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenming","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Vascular-Thyroid-Breast Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahong","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2931-1817","authenticated-orcid":true,"given":"Zhen","family":"Shan","sequence":"additional","affiliation":[{"name":"Center of Vascular-Thyroid-Breast Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198503143121101"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa020128"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(14)71156-8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)61950-9"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2836"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.07.1996"},{"key":"8","article-title":"A comparison of intra-operative radiotherapy boost with external beam radiotherapy boost in early breast cancer","author":"US National Library of Medicine","year":"2019"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/acm.0000000000000786"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4040"},{"key":"13","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"P. 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