{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:35:48Z","timestamp":1775885748404,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172478"],"award-info":[{"award-number":["82172478"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["tsqn201909190"],"award-info":[{"award-number":["tsqn201909190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021KJ048"],"award-info":[{"award-number":["2021KJ048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022T150340"],"award-info":[{"award-number":["2022T150340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021M701813"],"award-info":[{"award-number":["2021M701813"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021-NCRC-CXJJ-ZH-02"],"award-info":[{"award-number":["2021-NCRC-CXJJ-ZH-02"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["82172478"],"award-info":[{"award-number":["82172478"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tsqn201909190"],"award-info":[{"award-number":["tsqn201909190"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["2021KJ048"],"award-info":[{"award-number":["2021KJ048"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["2022T150340"],"award-info":[{"award-number":["2022T150340"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["2021M701813"],"award-info":[{"award-number":["2021M701813"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["2021-NCRC-CXJJ-ZH-02"],"award-info":[{"award-number":["2021-NCRC-CXJJ-ZH-02"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015642","name":"Project of Shandong Province Higher Educational Science and Technology Program","doi-asserted-by":"publisher","award":["82172478"],"award-info":[{"award-number":["82172478"]}],"id":[{"id":"10.13039\/501100015642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015642","name":"Project of Shandong Province Higher Educational Science and Technology Program","doi-asserted-by":"publisher","award":["tsqn201909190"],"award-info":[{"award-number":["tsqn201909190"]}],"id":[{"id":"10.13039\/501100015642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015642","name":"Project of Shandong Province Higher Educational Science and Technology Program","doi-asserted-by":"publisher","award":["2021KJ048"],"award-info":[{"award-number":["2021KJ048"]}],"id":[{"id":"10.13039\/501100015642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015642","name":"Project of Shandong Province Higher Educational Science and Technology Program","doi-asserted-by":"publisher","award":["2022T150340"],"award-info":[{"award-number":["2022T150340"]}],"id":[{"id":"10.13039\/501100015642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015642","name":"Project of Shandong Province Higher Educational Science and Technology Program","doi-asserted-by":"publisher","award":["2021M701813"],"award-info":[{"award-number":["2021M701813"]}],"id":[{"id":"10.13039\/501100015642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015642","name":"Project of Shandong Province Higher Educational Science and Technology Program","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/501100015642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015642","name":"Project of Shandong Province Higher Educational Science and Technology Program","doi-asserted-by":"publisher","award":["2021-NCRC-CXJJ-ZH-02"],"award-info":[{"award-number":["2021-NCRC-CXJJ-ZH-02"]}],"id":[{"id":"10.13039\/501100015642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["82172478"],"award-info":[{"award-number":["82172478"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["tsqn201909190"],"award-info":[{"award-number":["tsqn201909190"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021KJ048"],"award-info":[{"award-number":["2021KJ048"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022T150340"],"award-info":[{"award-number":["2022T150340"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M701813"],"award-info":[{"award-number":["2021M701813"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021-NCRC-CXJJ-ZH-02"],"award-info":[{"award-number":["2021-NCRC-CXJJ-ZH-02"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019598","name":"Applied Basic Research Fund of Qingdao","doi-asserted-by":"publisher","award":["82172478"],"award-info":[{"award-number":["82172478"]}],"id":[{"id":"10.13039\/501100019598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019598","name":"Applied Basic Research Fund of Qingdao","doi-asserted-by":"publisher","award":["tsqn201909190"],"award-info":[{"award-number":["tsqn201909190"]}],"id":[{"id":"10.13039\/501100019598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019598","name":"Applied Basic Research Fund of Qingdao","doi-asserted-by":"publisher","award":["2021KJ048"],"award-info":[{"award-number":["2021KJ048"]}],"id":[{"id":"10.13039\/501100019598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019598","name":"Applied Basic Research Fund of Qingdao","doi-asserted-by":"publisher","award":["2022T150340"],"award-info":[{"award-number":["2022T150340"]}],"id":[{"id":"10.13039\/501100019598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019598","name":"Applied Basic Research Fund of Qingdao","doi-asserted-by":"publisher","award":["2021M701813"],"award-info":[{"award-number":["2021M701813"]}],"id":[{"id":"10.13039\/501100019598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019598","name":"Applied Basic Research Fund of Qingdao","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/501100019598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019598","name":"Applied Basic Research Fund of Qingdao","doi-asserted-by":"publisher","award":["2021-NCRC-CXJJ-ZH-02"],"award-info":[{"award-number":["2021-NCRC-CXJJ-ZH-02"]}],"id":[{"id":"10.13039\/501100019598","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth Talent Assistance Program of Medical College of Qingdao University","award":["82172478"],"award-info":[{"award-number":["82172478"]}]},{"name":"Youth Talent Assistance Program of Medical College of Qingdao University","award":["tsqn201909190"],"award-info":[{"award-number":["tsqn201909190"]}]},{"name":"Youth Talent Assistance Program of Medical College of Qingdao University","award":["2021KJ048"],"award-info":[{"award-number":["2021KJ048"]}]},{"name":"Youth Talent Assistance Program of Medical College of Qingdao University","award":["2022T150340"],"award-info":[{"award-number":["2022T150340"]}]},{"name":"Youth Talent Assistance Program of Medical College of Qingdao University","award":["2021M701813"],"award-info":[{"award-number":["2021M701813"]}]},{"name":"Youth Talent Assistance Program of Medical College of Qingdao University","award":["2020"],"award-info":[{"award-number":["2020"]}]},{"name":"Youth Talent Assistance Program of Medical College of Qingdao University","award":["2021-NCRC-CXJJ-ZH-02"],"award-info":[{"award-number":["2021-NCRC-CXJJ-ZH-02"]}]},{"name":"Innovation Fund of National Orthopedics and Sports Rehabilitation Clinical Medicine Research Center","award":["82172478"],"award-info":[{"award-number":["82172478"]}]},{"name":"Innovation Fund of National Orthopedics and Sports Rehabilitation Clinical Medicine Research Center","award":["tsqn201909190"],"award-info":[{"award-number":["tsqn201909190"]}]},{"name":"Innovation Fund of National Orthopedics and Sports Rehabilitation Clinical Medicine Research Center","award":["2021KJ048"],"award-info":[{"award-number":["2021KJ048"]}]},{"name":"Innovation Fund of National Orthopedics and Sports Rehabilitation Clinical Medicine Research Center","award":["2022T150340"],"award-info":[{"award-number":["2022T150340"]}]},{"name":"Innovation Fund of National Orthopedics and Sports Rehabilitation Clinical Medicine Research Center","award":["2021M701813"],"award-info":[{"award-number":["2021M701813"]}]},{"name":"Innovation Fund of National Orthopedics and Sports Rehabilitation Clinical Medicine Research Center","award":["2020"],"award-info":[{"award-number":["2020"]}]},{"name":"Innovation Fund of National Orthopedics and Sports Rehabilitation Clinical Medicine Research Center","award":["2021-NCRC-CXJJ-ZH-02"],"award-info":[{"award-number":["2021-NCRC-CXJJ-ZH-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2023,7,10]]},"abstract":"<jats:p>There is no effective treatment for peripheral nerve injury-induced chronic neuropathic pain (NP), which profoundly impacts the quality of life of those affected. Transmembraneprotein100 (TMEM100) is considered to be a pain regulatory protein and is expressed in the dorsal root ganglion (DRG) of rats. However, the mechanism of pain regulation and the expression of TMEM100 following various peripheral nerve injuries are unclear. In this study, we constructed two pain models of peripheral nerve injury: tibial nerve injury (TNI) and chronic constriction injury (CCI). This study found that the Paw Withdrawal Mechanical Threshold (PWMT) and Paw Withdraw Thermal Latency (PWTL) of the rats in the two pain models decreased significantly, and the expression of TMEM100 in the DRG of two groups also decreased significantly. Furthermore, the decrease in the CCI group was more obvious than in the TNI group. There was no significant statistical significance (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). We constructed an adeno-associated virus 6 (AAV6) vector expressing recombinant fluorescent TMEM100 protein and injected it into the sciatic nerve (SN) of two pain models: CCI and TNI. PWMT and PWTL were significantly increased in the two groups, along with the expression of TMEM100 in the spinal cord and DRG. It also significantly inhibited the activation of microglia, astrocytes, and several inflammatory mediators (TNF- \u03b1, IL-1 \u03b2, and IL-6). In summary, the results of this study suggested that TMEM100 might be a promising molecular strategy for the treatment of NP, and its anti-inflammatory effects might play an important role in pain relief.<\/jats:p>","DOI":"10.1155\/2023\/9151967","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:05:28Z","timestamp":1689033928000},"page":"1-14","source":"Crossref","is-referenced-by-count":7,"title":["TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3838-9507","authenticated-orcid":true,"given":"Huifei","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-4170","authenticated-orcid":true,"given":"Zhaoyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"},{"name":"Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-5357","authenticated-orcid":true,"given":"Zhu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0296-6485","authenticated-orcid":true,"given":"Zuoran","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-3733","authenticated-orcid":true,"given":"Nana","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, The Affiliated Hospital of Qingdao University, Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8046-7547","authenticated-orcid":true,"given":"Xiaoying","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9884-206X","authenticated-orcid":true,"given":"Yuanye","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-4187","authenticated-orcid":true,"given":"Youfu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-7000","authenticated-orcid":true,"given":"Xiaolin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-4352","authenticated-orcid":true,"given":"Bohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5026-5918","authenticated-orcid":true,"given":"Hongfei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.06.017"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.180"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8685954"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2009.00655.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122725"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70102-4"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7656"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000703"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.02.034"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu260"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207210109"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27426"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.065"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916668526"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.04.014"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0565-z"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.058966"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32834871df"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01014"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8924"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.100"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001122"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.12.010"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23723"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.1.442"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0930324100"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-5-52"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-31"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200003200-00002"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2102"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"issue":"5","key":"35","first-page":"2567","article-title":"Low-expression of TMEM100 is associated with poor prognosis in non-small-cell lung cancer","volume":"9","author":"Z. Han","year":"2017","journal-title":"American Journal of Translational Research"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20674"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2009.08.010"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.10.036"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.02.028"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.07.027"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004109"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113503"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2234"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.022"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-33"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611048104"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.006"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1932-8494"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2533"},{"key":"50","article-title":"TMEM100 regulates neuropathic pain by reducing the expression of inflammatory factors","author":"Z. Guo","year":"2022"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/9151967.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/9151967.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/9151967.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:05:42Z","timestamp":1689033942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2023\/9151967\/"}},"subtitle":[],"editor":[{"given":"Cheorl-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":50,"alternative-id":["9151967","9151967"],"URL":"https:\/\/doi.org\/10.1155\/2023\/9151967","relation":{},"ISSN":["1466-1861","0962-9351"],"issn-type":[{"value":"1466-1861","type":"electronic"},{"value":"0962-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,10]]}}}