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The etiology of RPL is complex, involving chromosomal abnormalities, autoimmune diseases, metabolic disorders, and endometrial dysfunction. The causes of abortion are still unknown in more than 50% of these cases. With the development of science and technology, an increasing number of scholars focus on this field and find that genetic factors may play an essential role in unexplained RPL, such as embolism-related genes, immune factor-related genes, and chromosomal numeric, and structural variation. This review summarizes the genetic factors associated with RPL, including genetic mutations and genetic polymorphisms, chromosomal variants, and chromosomal polymorphisms. Many related genetic factors have been found to be demographically and geographically relevant, some of which can be used for risk prediction or screening for the etiology of RPL. However, it is difficult to predict and prevent RPL due to uncertain pathogenesis and highly variable clinical presentation. Therefore, the genetic factors of RPL still need plentiful research to obtain a more accurate understanding of its pathogenesis and to provide more detection means for the screening and prevention of RPL.<\/jats:p>","DOI":"10.1155\/2023\/9164374","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T23:50:05Z","timestamp":1679701805000},"page":"1-16","source":"Crossref","is-referenced-by-count":29,"title":["The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss"],"prefix":"10.1155","volume":"2023","author":[{"given":"Qinlan","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Male Reproduction and Genetics (Family Planning Research Institute of Guangdong Province), Guangzhou 510600, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6932-2620","authenticated-orcid":true,"given":"Yonghong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women\u2019s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2291-2524","authenticated-orcid":true,"given":"Donghui","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.826198"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S100817"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00228-z"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del150"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.11.025"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082267"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.10.002"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31802f1c28"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp1005330"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000214"},{"issue":"7","key":"11","first-page":"1243","article-title":"Management of spontaneous abortion","volume":"72","author":"C. 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