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However, there is a paucity of data reporting immunoglobulin G (IgG) subclass in coal workers\u2019 pneumoconiosis (CWP). Therefore, this study intended to evaluate potential diagnostic biomarkers for the disease. CWP patients, dust-exposed workers without pneumoconiosis (DEW), and matched healthy controls (HCs) presented to the General Hospital of Datong Coal Mining Group and Occupational Disease Prevention and Treatment Hospital of Datong Coal Mining Group between May 2019 and September 2019 were recruited. The serum immunoglobulin concentration was determined by the multiplex immunoassay technique. Totally, 104 CWP patients, 109 DEWs, and 74 HCs were enrolled. Serum levels of IgG1, IgG2, IgM, and IgA were elevated in CWPs compared with those in DEWs and HCs (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The order of diagnostic accuracy between CWPs and DEWs depicted by the receiver operating characteristic (ROC) curve was IgG2, IgM, IgG1, IgG3, and IgA. Significantly higher IgG1\/IgG3 and IgG2\/IgG3 ratios were observed in the CWP group than in DEW and HC groups. Based on the IgG2\/IgG3 ratio, the area under the ROC curve between CWP and DEW was 0.785 (95% CI 0.723-0.838), with a sensitivity of 73.1% and a specificity of 73.4%. Our findings suggest that IgG1, IgG2, IgM, and IgA are higher in the CWPs than DEWs and HCs. The IgG2\/IgG3 ratio provides a viable alternative for the diagnosis of CWP.<\/jats:p>","DOI":"10.1155\/2023\/9233386","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T22:32:09Z","timestamp":1678919529000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["The Potential Diagnostic Biomarkers for the IgG Subclass in Coal Workers\u2019 Pneumoconiosis"],"prefix":"10.1155","volume":"2023","author":[{"given":"Zhao-Guo","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086 Heilongjiang, China"},{"name":"Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Cun","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100730, China"},{"name":"First Clinical College, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, General Hospital of Datong Coal Mine Group Co., Ltd, Datong 037000, China"},{"name":"Department of Pulmonary and Critical Care Medicine, The First Hospital of Shanxi Medical University, Taiyuan 030001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cao","sequence":"additional","affiliation":[{"name":"Occupational Disease Prevention and treatment Hospital of Datong Coal Mine Group Co., Ltd, Datong 037001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hua","family":"Yu","sequence":"additional","affiliation":[{"name":"Occupational Disease Prevention and treatment Hospital of Datong Coal Mine Group Co., Ltd, Datong 037001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-1582","authenticated-orcid":true,"given":"Hua-Ping","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China\u2013Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Disease, Beijing 100029, China"},{"name":"National Center for Respiratory Medicine; 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