{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:35:16Z","timestamp":1790087716830,"version":"4.0.1"},"reference-count":86,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:p>Inflammatory fibroid polyp (IFP), initially considered a reactive process, is now recognized as a benign mesenchymal neoplasm of the gastrointestinal tract. We report a case of a 68-year-old woman with medically refractory Crohn disease that presented with intussusception requiring surgical intervention. The resection revealed a jejunal mass consisting of a submucosal proliferation of bland spindle cells in a fibrous stroma infiltrated by numerous eosinophils. By immunohistochemistry, the lesion was positive for vimentin and negative for desmin, smooth muscle actin (SMA), S-100, CD117, DOG1, ALK (D5F3), Melan-A, HMB-45, CD34, and STAT6. Ki-67 proliferative index was low (&lt;1%). The mass was classified as IFP by its characteristic morphology and associated eosinophilia. IFP should be considered in the differential diagnosis of adults with intussusception or bowel obstruction. Definitive treatment typically requires surgical resection of the involved bowel segment.<\/jats:p>","DOI":"10.1155\/2023\/9417141","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T21:50:10Z","timestamp":1681422610000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Jejunal Intussusception Secondary to a Large Inflammatory Fibroid Polyp: A Case Report and Discussion of Differential Diagnosis"],"prefix":"10.1155","volume":"2023","author":[{"given":"Asma Khalid","family":"Abu-Salah","sequence":"first","affiliation":[{"name":"Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Brocken","sequence":"additional","affiliation":[{"name":"Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Mesa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-6731","authenticated-orcid":true,"given":"Katrina","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.1994.9.1.51"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1978.tb01727.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/81.6.708"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2003.09.003"},{"issue":"3","key":"5","first-page":"335","article-title":"Inflammatory fibroid polyps of the stomach","volume":"96","author":"E. B. Helwig","year":"1953","journal-title":"Surgery, Gynecology & Obstetrics"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006131"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079666"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31827ae11e"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0808-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/path.2393"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3499-7"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.62"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1950.82910410008009"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00957487"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.4.420"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197703000-00011"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1981.tb01777.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830501)51:9<1682::AID-CNCR2820510921>3.0.CO;2-P"},{"issue":"7","key":"19","first-page":"598","article-title":"Inflammatory fibroid polyp of the jejunum causing intussusception","volume":"81","author":"H. Winkler","year":"1986","journal-title":"The American Journal of Gastroenterology"},{"issue":"2","key":"20","first-page":"127","article-title":"Inflammatory fibroid polyp of the jejunum causing intussusception: a case report","volume":"53","author":"C. C. Ling","year":"1994","journal-title":"Zhongua Yi Xue Za Zhi"},{"issue":"1","key":"21","first-page":"71","article-title":"Intestinal obstruction with invagination causing an inflammatory fibroid polyp of the small intestine","volume":"65","author":"D. Oertli","year":"1994","journal-title":"Der Chirurg"},{"issue":"1","key":"22","first-page":"162","article-title":"Inflammatory fibroid polyp of the jejunum causing intussusception","volume":"92","author":"L. N. Shih","year":"1997","journal-title":"The American Journal of Gastroenterology"},{"issue":"1","key":"23","first-page":"170","article-title":"Could a fibroid polyp be a manifestation of enteropathy induced by nonsteroidal anti-inflammatory drugs?","volume":"92","author":"O. Muniz-Grijalvo","year":"1997","journal-title":"The American Journal of Gastroenterology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.19.2.g99mr19539"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1159\/000050116"},{"issue":"1","key":"26","first-page":"119","article-title":"Inflammatory fibroid polyp of the jejunum presenting as intussusception","volume":"45","author":"S. P. Sah","year":"2002","journal-title":"Indian Journal of Pathology & Microbiology"},{"key":"27","first-page":"ccliv","article-title":"Jejunal intussusception caused by an inflammatory fibroid polyp","volume":"50","author":"S. Topaloglu","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000043385.44842.c8"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-814305"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-813694"},{"issue":"5","key":"31","first-page":"190","article-title":"Inflammatory fibroid polyp of jejunum causing jejuno-jejunal intussusception","volume":"23","author":"R. Vijayaraghavan","year":"2004","journal-title":"Indian Journal of Gastroenterology"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1157\/13073089"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S1015-9584(09)60262-1"},{"issue":"2","key":"34","first-page":"108","article-title":"Jejunojejunal intussusception caused by an inflammatory fibroid polyp. Case report and review of the literature","volume":"55","author":"I. I. El Hajj","year":"2007","journal-title":"Le Journal M\u00e9dical Libanais"},{"key":"35","first-page":"1","article-title":"Adult intussusception from an inflammatory fibroid polyp: a case report and review of the literature [Internet]","volume":"7","author":"S. O. Cawich","year":"2008","journal-title":"The Journal of Pathology"},{"issue":"2","key":"36","first-page":"122","article-title":"Inflammatory fibroid polyp of the small bowel causing intestinal obstruction due to intussusception \u2013 a case report","volume":"3","author":"A. Szczepanowski","year":"2009","journal-title":"Journal of Pre-Clinical and Clinical Research"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1985"},{"key":"38","first-page":"3241","article-title":"Inflammatory fibroid polyp of small intestine: report of two cases with review of literature","volume":"4","author":"M. Singhal","year":"2010","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2015.31.3.106"},{"issue":"2","key":"40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3329\/imcj.v9i2.28856","article-title":"Jejunal inflammatory fibroid polyp: a rare cause of intussusception","volume":"9","author":"M. R. H. Talukder","year":"2016","journal-title":"Ibrahim Medical College Journal"},{"issue":"10","key":"41","first-page":"714","article-title":"Clinicopathologic features of inflammatory fibroid polyp in gastrointestinal tract","volume":"44","author":"J. Wei","year":"2015","journal-title":"Zhonghua Bing Li Zue Za Zhi"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022080"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9251042"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.17992\/lbl.2020.0708.591"},{"issue":"2","key":"45","first-page":"280","article-title":"Recurrent eosinophilic infiltrate (granuloma) of the ileum causing intussusception in a two-year-old child","volume":"61","author":"P. McGreevy","year":"1967","journal-title":"Surgery"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000062860.60390.C7"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1097\/00129039-200403000-00011"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e318050aa66"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpr.2021.300550"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13748"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.56"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0715-5"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04203.x"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000338"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200407000-00007"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050679"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200109000-00002"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181d27ec8"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2011.11.006"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.8961"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.5301\/tj.5000353"},{"key":"62","volume-title":"Soft Tissue and Bone Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020","edition":"5th"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24684"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213393.57322.c7"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1007\/BF02456289"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.32213"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20516"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/94.5.538"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.23970"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.049387"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4182026"},{"issue":"9","key":"72","first-page":"11691","article-title":"Solitary fibrous tumor of small bowel mesentery with postoperative bowel obstruction: a case report and review of literature","volume":"8","author":"G. J. Zhang","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01638.x"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1111\/his.13050"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-227238"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2009.0014"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.126469"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/324538"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-228774"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1159\/000499137"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520950111"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehpc.2021.200547"},{"key":"83","first-page":"86","article-title":"Extrapleural solitary fibrous tumor and haemangiopericytoma","volume-title":"Pathology and Genetics of Tumors of Soft Tissue and Bone","author":"L. Guillou","year":"2002"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.164"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6983460"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.132"}],"container-title":["Case Reports in Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2023\/9417141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2023\/9417141.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2023\/9417141.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T21:50:30Z","timestamp":1681422630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cripa\/2023\/9417141\/"}},"subtitle":[],"editor":[{"given":"Mirella","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,4,13]]},"references-count":86,"alternative-id":["9417141","9417141"],"URL":"https:\/\/doi.org\/10.1155\/2023\/9417141","relation":{},"ISSN":["2090-679X","2090-6781"],"issn-type":[{"value":"2090-679X","type":"electronic"},{"value":"2090-6781","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,13]]}}}