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A diverse set of 40 DICER1 variants were selected for piloting, including 14 known pathogenic\/likely pathogenic (P\/LP) variants, 12 known benign\/likely benign (B\/LB) variants, and 14 variants classified as variants of uncertain significance (VUS) or with conflicting interpretations in ClinVar. Clinically meaningful classifications (i.e., P, LP, LB, or B) were achieved for 82.5% (33\/40) of the pilot variants, with 100% concordance among the known P\/LP and known B\/LB variants. Half of the VUS or conflicting variants were resolved with four variants classified as LB and three as LP. These results demonstrate that the DICER1-specific guidelines for germline variant curation effectively classify known pathogenic and benign variants while reducing the frequency of uncertain classifications. 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