{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:05:06Z","timestamp":1765422306756,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2023,2,8]]},"abstract":"<jats:p>Background. In recent years, immune checkpoint inhibitors (ICI) have been often used for several types of cancers. Immune-related adverse events (irAEs) are autoimmune responses caused by ICI. Among the different types of irAEs, uveitis is common in ophthalmology. Moreover, there are reports on Vogt\u2013Koyanagi\u2013Harada (VKH) disease-like uveitis. In most cases, VKH, as in the usual VKH, is managed with intravenous methylprednisolone therapy. Case Report. A 72-year-old man was diagnosed with gastric cancer, and he was treated with nivolumab, a type of ICI. After eight cycles of nivolumab therapy, he developed fulminant type 1 diabetes mellitus and diabetic ketoacidosis. Thus, the treatment was discontinued. Subsequently, the patient was referred to our department due to bilateral blurry vision. He had decreased visual acuity in both eyes, and slit lamp examination revealed the presence of bilateral anterior chamber cells and keratic precipitates. Fundus examination showed bilateral serous retinal detachment (SRD), wavy retinal pigment epithelium (RPE), and choroidal thickening. Cerebrospinal fluid examination revealed prominent pleocytosis. Thus, we initiated eye drop therapy and subtenon injection of triamcinolone acetonide on the right eye only. After 1 month, SRD and wavy RPE disappeared, and the patient\u2019s visual acuity improved. Further, both eyes had similar improvements in visual acuity and abnormal findings. Oral prednisolone was subsequently administered for hearing loss. However, intravenous methylprednisolone was not used, and ophthalmologic findings and visual acuity did not change before and after systemic steroid therapy. One year after disease onset, SRD and wavy RPE did not relapse. Conclusion. Nivolumab-induced VKH disease-like uveitis can have good outcomes even in a patient managed without intravenous methylprednisolone therapy.<\/jats:p>","DOI":"10.1155\/2023\/9565205","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T23:20:36Z","timestamp":1675898436000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of Nivolumab-Induced Vogt\u2013Koyanagi\u2013Harada Disease-Like Uveitis in a Patient Managed without Intravenous Methylprednisolone Therapy"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7017-3674","authenticated-orcid":true,"given":"Ryoji","family":"Nagai","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Nishi-Kobe Medical Center, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinari","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nishi-Kobe Medical Center, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Mikawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nishi-Kobe Medical Center, Kobe, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0329-9"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1773867"},{"issue":"6","key":"3","first-page":"635","article-title":"Guidelines for Uveitis","volume":"123","author":"Japanese Ocular Inflammation Society","year":"2019","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.05.002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/8.5.799"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.11.1002"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1273"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-021-09862-8"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1159\/000520416"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.6410-20"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14640"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000001165"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1055\/a-1306-0854"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-019-00963-z"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2019-0206"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01519-5"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1159\/000496682"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14273"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13612"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.911"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1781902"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.01.017"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_787_19"},{"key":"24","first-page":"1601","article-title":"Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients","volume":"12","author":"Y. Horie","year":"2006","journal-title":"Molecular Vision"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30920-7"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2023\/9565205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2023\/9565205.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2023\/9565205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T23:20:38Z","timestamp":1675898438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criopm\/2023\/9565205\/"}},"subtitle":[],"editor":[{"given":"Benedetto","family":"Falsini","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,8]]},"references-count":26,"alternative-id":["9565205","9565205"],"URL":"https:\/\/doi.org\/10.1155\/2023\/9565205","relation":{},"ISSN":["2090-6730","2090-6722"],"issn-type":[{"type":"electronic","value":"2090-6730"},{"type":"print","value":"2090-6722"}],"subject":[],"published":{"date-parts":[[2023,2,8]]}}}