{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:54:22Z","timestamp":1790456062456,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2023,5,29]]},"abstract":"<jats:p>There is little evidence concerning the need to treat gestational diabetes (GDM) in the same way as pregestational diabetes. We evaluated the efficacy of the simple insulin injection (SII) regimen for achieving the target glucose goal without increasing adverse perinatal outcomes in singleton pregnant women with GDM. All subjects underwent self-monitoring of blood glucose (SMBG), and insulin therapy was indicated according to the SMBG profile. Insulin was initially started with the SII regimen, in which one daily injection of NPH insulin before breakfast was used, and another NPH injection was added at bedtime, if necessary. We used the target glucose as &lt;95\u2009mg\/dL at fasting and &lt;120\u2009mg\/dL postprandial and accepted &lt;130\u2009mg\/dL for the latter. If the target glucose did not reach with the regimen, we switched to the multiple daily injection (MDI) with additional prandial insulin aspart. We compared the SMBG profile before delivery as well as the perinatal outcomes between the SII and MDI groups. Among 361 women (age 33.7 years, nullipara 41%, prepregnancy body mass index 23.2\u2009kg\/m2) with GDM, 59%, 18%, and 23% were in the diet-alone, SII, and MDI groups, respectively. Consequently, regarding women requiring insulin therapy, 43% were treated with the SII regimen throughout pregnancy. The severity of baseline hyperglycemia according to the SMBG data at baseline was the MDI&gt;the SII&gt;the diet group. The rate of achieving target glucose levels before delivery in the SII group at fasting, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>postprandial<\/a:mtext>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>120<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009mg\/dL and &lt;130\u2009mg\/dL were 93%, 54% and 87%, respectively, which were similar to that in the MDI group (93%, 57%, and 93%, respectively), with no significant differences in perinatal outcomes. In conclusion, more than 40% of women with GDM requiring insulin therapy achieved the target glucose goal with this simple insulin regimen without any increase in adverse effects.<\/jats:p>","DOI":"10.1155\/2023\/9574563","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T04:52:05Z","timestamp":1685508725000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["Achievement of Target Glycemic Goal with Simple Basal Insulin Regimen in Women with Gestational Diabetes: A Prospective Cohort Study"],"prefix":"10.1155","volume":"2023","author":[{"given":"Misao","family":"Fukuoka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-9175","authenticated-orcid":true,"given":"Ichiro","family":"Yasuhi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Ashimoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"},{"name":"Department of Obstetrics and Gynecology, Kameda General Hospital, Kamogawa, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Kurata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So","family":"Sugimi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachie","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Hospital Organization (NHO) Nagasaki Medical Center, Omura-City, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.04.006"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042973"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902430"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1177\/0145721714535991"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2174\/157339906777950615"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12354"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3127"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01653.x"},{"key":"10","first-page":"871","article-title":"Diabetes mellitus complicating pregnancy","volume-title":"Obstetrics: Normal and Problem Pregnancies","author":"M. 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