{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:17:46Z","timestamp":1771467466860,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["20201917"],"award-info":[{"award-number":["20201917"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:p>Accumulating evidence has noted the circRNA-microRNA- (circRNA-miRNA-) mRNA competing endogenous RNA (ceRNA) regulatory network in disease development and progression. The current study explored the ceRNA network in acute traumatic coagulopathy (ATC). Potential ATC-related genes were screened, and upstream miRNAs and circRNAs of VWF (the candidate target) were assayed through database searching and high-throughput sequencing technology. circ_0001274\/miR-143-3p\/VWF ceRNA regulatory network was constructed and validated. The expression of circ_0001274\/miR-143-3p\/VWF was determined in the peripheral blood samples from ATC patients and ATC mouse models. Online database and circRNA sequencing analysis results identified VWF as a key gene in ATC as supported by assays and that VWF was lowly expressed in ATC patients and mice. Further experiments demonstrated that miR-143-3p could target and inhibit VWF, and circ_0001274 could competitively sponge miR-143-3p. Functionally, circ_0001274 could competitively sequester miR-143-3p to upregulate VWF expression, potentially improving ATC. Our study highlights the critical role of circ_0001274\/miR-143-3p\/VWF axis in improving ATC.<\/jats:p>","DOI":"10.1155\/2023\/9650323","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T16:02:38Z","timestamp":1675180958000},"page":"1-18","source":"Crossref","is-referenced-by-count":1,"title":["circ_0001274 Competitively Binds miR-143-3p to Upregulate VWF Expression to Improve Acute Traumatic Coagulopathy"],"prefix":"10.1155","volume":"2023","author":[{"given":"Yong","family":"Luo","sequence":"first","affiliation":[{"name":"Hengyang Medical School, University of South China, Hengyang 421001, China"},{"name":"Trauma Center, Hengyang Medical School, The Second Affiliated Hospital, University of South China, Hengyang 421001, Hunan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Liu","sequence":"additional","affiliation":[{"name":"Trauma Center, Hengyang Medical School, The Second Affiliated Hospital, 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