{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:33:12Z","timestamp":1790721192812,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":198,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2011CB505203"],"award-info":[{"award-number":["2011CB505203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603652"],"award-info":[{"award-number":["81603652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","award":["YESS20200255"],"award-info":[{"award-number":["YESS20200255"]}],"id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The aim of the study is to investigate the serum metabolomics of electroacupuncture (EA) with different current intensities in the treatment of functional constipation (FC). <jats:italic>Methods<\/jats:italic>. The total number of FC patients was 19, (7, 6, 6, in the low current intensity group (LCI), high current intensity group (HCI), and mosapride citrate tablet control group (MC), respectively). Patients in the EA groups received 16 sessions of acupuncture treatments. Patients in the MC group were orally administered 5\u2009mg mosapride citrate tablets 3 times daily, and serum samples were collected from the patients before and after treatment. Orthogonal partial least square\u2010discriminant analysis (OPLS\u2010DA) was used to assess the metabolic data. The significant differences before and after FC treatment are shown in the OPLS\u2010DA score plot. Variable importance plots (VIPs) and <jats:italic>T<\/jats:italic> tests were used to identify significant metabolites. <jats:italic>Results<\/jats:italic>. Among the three groups, the number of metabolites with VIP\u2009&gt;\u20091 was 11, 7, and 21 (in LCI, HCI and MC groups, respectively). Compared with those before treatment, the serum metabolites of patients were characterized by increased levels of L\u2010ornithine (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and glyceric acid in the LCI group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), increased levels of vanillic acid in the MC group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and decreased levels of arabinonic acid in the MC group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). <jats:italic>Conclusions<\/jats:italic>. The effects of EA treatment on the serum metabolomics of FC may involve fatty acid and amino acid metabolism.<\/jats:p>","DOI":"10.1155\/2023\/9693390","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T22:35:22Z","timestamp":1689719722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Electroacupuncture with Different Current Intensities on the Serum Metabolomics of Functional Constipation"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-6065","authenticated-orcid":false,"given":"Xiao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-964X","authenticated-orcid":false,"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-1205","authenticated-orcid":false,"given":"Guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-0264","authenticated-orcid":false,"given":"CuiHong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-3900","authenticated-orcid":false,"given":"Haoxu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1144-0912","authenticated-orcid":false,"given":"Fan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-9240","authenticated-orcid":false,"given":"Mingmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-759X","authenticated-orcid":false,"given":"Guangyin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-5654","authenticated-orcid":false,"given":"Xiaohu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007137"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01401.x"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03809.x"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.073197"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2010.07.002"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005350200150"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2019.23.5.419"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-014-0751-4"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-20-280"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00423"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.112837"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1428943"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.008"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043389"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2015-010897"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058204"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001050"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00018.2018"},{"key":"e_1_2_12_19_2","first-page":"1","article-title":"The effect and mechanism of electroacupuncture at LI11 and ST37 on constipation in a rat model","volume":"17","author":"Zhu X. 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