{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:30:11Z","timestamp":1788294611379,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016029","name":"Amhara Regional Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005872","name":"Bahir Dar University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005872","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2023,6,26]]},"abstract":"<jats:p>Background. Soil-transmitted helminths are parasitic nematodes found in the intestine. They are more prevalent in the tropics and subtropics, including Ethiopia. However, low-sensitive direct wet mount microscopy fails to detect soil-transmitted helminths among infected cases. Therefore, more sensitive and cost-effective diagnostic methods are urgently needed to minimize soil-transmitted helminthiasis morbidity. Objective. This study aimed to compare and evaluate the performance of diagnostic methods for soil-transmitted helminths against the \u201cgold\u201d standard. Methods. An institution-based cross-sectional study was conducted among 421 schoolchildren from May to July, 2022 in the Amhara Region. Study participants were selected using a systematic random sampling technique. Stool samples were processed via Kato\u2013Katz, McMaster, and spontaneous tube sedimentation techniques. Data were entered into epi-data version 3.1 and analyzed using SPSS version 25. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated against the combined result as a \u201cgold\u201d standard. The strength of agreement between the diagnostic methods was determined by the Kappa value. Results. The overall prevalence of soil-transmitted helminths was 32.8% (95% CI: 28.2\u201337.8%) using a combination of methods. The detection rates of Kato\u2013Katz, McMaster, and spontaneous tube sedimentation were 28.5% (95% CI: 24.2\u201333.2%), 30% (95% CI: 25.6\u201334.8%), and 30.5% (95% CI: 26.1\u201335.3%), respectively. Sensitivity and negative predictive values were 87.1% (95% CI: 80.2\u201392.3%) and 95.1% (95% CI: 92.6\u201396.8%) for Kato\u2013Katz; 91.7% (95% CI: 85.6\u201395.6%) and 96.5% (95% CI: 94.1\u201398.0%) for McMaster; and 93.2% (95% CI: 87.5\u201396.8%) and 97.1% (95% CI: 94.7\u201398.4%) for spontaneous tube sedimentation. Kappa values of Kato\u2013Katz, McMaster, and spontaneous tube sedimentation for the diagnosis of soil-transmitted helminths were 0.901, 0.937, and 0.948, respectively. Conclusion. Kato\u2013Katz, McMaster, and spontaneous tube sedimentation techniques had comparable sensitivity with almost perfect agreement for the detection of soil-transmitted helminths. Therefore, the spontaneous tube sedimentation technique can be used as an alternative diagnostic method for soil-transmitted helminth infections in endemic countries.<\/jats:p>","DOI":"10.1155\/2023\/9697165","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:20:05Z","timestamp":1687825205000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Performance Evaluation of Three Diagnostic Methods for Soil-Transmitted Helminth Infections among Schoolchildren in Amhara Region, Northwest Ethiopia"],"prefix":"10.1155","volume":"2023","author":[{"given":"Shegaw","family":"Belay","sequence":"first","affiliation":[{"name":"Amhara National Regional State Health Bureau, Bahir Dar Health Science College, Bahir Dar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-4176","authenticated-orcid":true,"given":"Getaneh","family":"Alemu","sequence":"additional","affiliation":[{"name":"Departments of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-1888","authenticated-orcid":true,"given":"Tadesse","family":"Hailu","sequence":"additional","affiliation":[{"name":"Departments of Medical Laboratory Science, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","article-title":"Chemotherapy coverage against Soil-transmitted helminthiases among school age children in vertical versus integrated treatment approaches: implications from coverage validation survey in Ethiopia","author":"MedRxiv","year":"2020"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(20)30398-3"},{"key":"3","article-title":"Soil-transmitted helminth infections","author":"Who","year":"2019"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007201"},{"key":"5","article-title":"Ministry of health, third edition of Ethiopia national master plan for neglected tropical diseases","author":"F. 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