{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:55:01Z","timestamp":1747191301946,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Virginia\u2019s Academic Library Consortium"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2023,6,21]]},"abstract":"<jats:p>Immune thrombocytopenia (ITP) is an acquired thrombocytopenia resulting from immune-mediated platelet destruction via antiplatelet antibodies and T cells. Medical management of ITP includes corticosteroids and multiple other adjunct therapies, with splenectomy generally being reserved for severe, refractory cases. In this clinical case report, we describe the evaluation of a 35-year-old male with a history of prior traumatic splenic injury who presented to the emergency department endorsing easy bruising and a petechial rash, ultimately found to have severe thrombocytopenia. The patient was diagnosed with primary ITP that proved to be refractory to a number of first- and second-line medical therapies. His course was complicated by the presence of abdominal splenosis discovered at the time of planned splenectomy and intra-abdominal hemorrhage requiring splenic artery embolization thereafter. To our knowledge, this is one of few published cases of ITP complicated by abdominal splenosis, highlighting the need to consider splenosis and the presence of accessory splenic tissue in cases of refractory ITP.<\/jats:p>","DOI":"10.1155\/2023\/9714457","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T15:38:58Z","timestamp":1687361938000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Refractory Immune Thrombocytopenic Purpura with Abdominal Splenosis: A Complex Case"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5168-4030","authenticated-orcid":true,"given":"Joseph F.","family":"Mort","sequence":"first","affiliation":[{"name":"University of Virginia, Department of Medicine, 1215 Lee Street Box 800466, Charlottesville, VA 22908, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danh T.","family":"Tran","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Medicine, 1215 Lee Street Box 800466, Charlottesville, VA 22908, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6076-7084","authenticated-orcid":true,"given":"Sean C.","family":"Dougherty","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Medicine, 1215 Lee Street Box 800466, Charlottesville, VA 22908, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Zielinski","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Medicine, 1215 Lee Street Box 800466, Charlottesville, VA 22908, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Surgery, 1300 Jefferson Park Avenue, Charlottesville, VA 22903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M.","family":"Davidson","sequence":"additional","affiliation":[{"name":"University of Virginia, Department of Medicine, Division of Hematology & Oncology, 1300 Jefferson Park Avenue Box 800716, Charlottesville, VA 22908, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-754119"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07615.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb18984.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nm921"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-129155"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000812"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90380-6"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1984.01390150081022"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpradiol.2020.04.012"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1259\/bjrcr.20180024"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8652(200009)65:1<56::aid-ajh10>3.0.co;2-1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519890200"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90804-5"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.5152\/UCD.2015.2746"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/00129689-200606000-00016"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021010968"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15090"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.1.56"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22011"},{"issue":"3","key":"21","first-page":"314","article-title":"Laparoscopic accessory splenectomy for recurrent idiopathic thrombocytopenic purpura","volume":"12","author":"Y. 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