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This study was performed to test this hypothesis and to explore the underlying mechanism. Male Wistar rats weighing 180\u2010220\u2009g were induced metabolic syndrome (MetS) with a 16\u2010week high\u2010carbohydrate high\u2010fat diet (HCHF) feeding. The rats with MetS characteristics were orally administered GCJ at various doses (GCJ100, GCJ200, and GCJ300 mg kg\n                    <jats:sup>-1<\/jats:sup>\n                    BW) 21 days pre\u2010induction and 21 days post\u2010induction of reperfusion injury (I\/R) at the right middle cerebral artery (MCAO). Memory was evaluated every 7 days during the study period. At the end of the study, neuron density, AChE activity, and the expressions of eNOS, BDNF, and pERK\/ERK in the prefrontal cortex, and hippocampus were also determined. MetS rats with GCJ treatment improved memory impairment, enhanced neuron density, and increased the expressions of eNOS, BDNF, and pERK\/ERK but suppressed AChE in both areas. Therefore, the anti\u2010dementia effect following ischemic stroke with metabolic syndrome of GCJ may involve the improvement of AChE, eNOS, BDNF, pERK\/ERK, and neural plasticity. However, this required confirmation by clinical study.\n                  <\/jats:p>","DOI":"10.1155\/2023\/9911397","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T12:05:34Z","timestamp":1690977934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Polyherbal Functional Ingredient Containing Ginger, Chinese Date, and Wood Ear Mushroom Protects against Dementia following Metabolic 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