{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:14:26Z","timestamp":1762474466550,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":318,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K11662"],"award-info":[{"award-number":["21K11662"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Growth Hormone therapy has been shown to induce transient insulin resistance in children, and there is concern regarding the diabetogenic potential of GH therapy in children born small for gestational age (SGA). In this case, female patient born SGA with a weight of 2,750\u2009g (\u22121.73 standard deviation (SD)) and length of 45.5\u2009cm (\u22122.6 SD). The patient\u2019s father and paternal grandfather were diagnosed with type 2 diabetes mellitus. At 3\u2009years of age, the patient presented with short stature; height and weight were 85\u2009cm (\u22122.5 SD) and 13\u2009kg (\u22120.19 SD), respectively. She was placed on GH therapy. At 11\u2009years of age, her fasting blood glucose and hemoglobin A1c levels were 116\u2009mg\/dL and 7.4%, respectively. Blood test results were negative for anti\u2010glutamic acid decarboxylase and anti\u2010islet antigen\u20102 antibodies. The patient discontinued GH therapy and started diet therapy and oral metformin (500\u2009mg\/day) administration. Five months later, the hemoglobin A1c level was 5.3% and glycemic control further improved. To our knowledge, family history may be an important risk factor for GH\u2010induced diabetes. So, the GH dosage for patients born SGA with family history of diabetes should be adjusted so as not to be too excessive, and long\u2010term follow\u2010up studies will be required to evaluate fully the effects of GH therapy for them.<\/jats:p>","DOI":"10.1155\/2023\/9912817","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:50:05Z","timestamp":1700074205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-2658","authenticated-orcid":false,"given":"Naohiro","family":"Nomura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-5952","authenticated-orcid":false,"given":"Yuko","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2185-8826","authenticated-orcid":false,"given":"Miki","family":"Minami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-9044","authenticated-orcid":false,"given":"Junji","family":"Takaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8215-0832","authenticated-orcid":false,"given":"Kazunari","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"350","article-title":"Growth and growth hormone treatment in short stature children born small for gestational age","volume":"6","author":"Labarta J.","year":"2009","journal-title":"Pediatric Endocrinology Reviews"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2019.03.012"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02171.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.ijem_91_18"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.ej12-0110"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1073"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(16)30422-3"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep38659"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v2i3.100"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-5-71"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2023\/9912817.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2023\/9912817.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2023\/9912817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:10:10Z","timestamp":1762474210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2023\/9912817"}},"subtitle":[],"editor":[{"given":"Nur","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1155\/2023\/9912817"],"URL":"https:\/\/doi.org\/10.1155\/2023\/9912817","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"type":"print","value":"2090-6803"},{"type":"electronic","value":"2090-6811"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2023-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9912817"}}