{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:23:59Z","timestamp":1790717039780,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170453"],"award-info":[{"award-number":["82170453"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2023,11,6]]},"abstract":"<jats:p>Introduction. Chronic total occlusion (CTO) of coronary arteries constitutes a substantial clinical challenge and has historically been managed through medical management and coronary artery bypass grafting (CABG). However, with the advancement in interventional technology, the success rate of percutaneous treatment has been significantly improved, and percutaneous coronary intervention (PCI) has emerged as a primary mode of treatment for CTOs, demonstrating remarkable clinical efficacy. The objective of this systematic review and meta-analysis is to evaluate and contrast the outcomes of PCI and CABG in patients with CTO. Methods and Results. A systematic search was conducted in the databases of PubMed, Embase, and Web of Science. The primary endpoints evaluated in this meta-analysis were the occurrence of major adverse cardiac events (MACE) and all-cause mortality. Secondary endpoints included myocardial infarction (MI), cardiac death, and the need for repeat revascularization. Nine studies, encompassing a total of 8,674 patients, were found to meet the criteria for inclusion and had a mean follow-up duration of 4.3\u2009years. The results of the meta-analysis revealed that compared to CABG, PCI was associated with a lower incidence of all-cause mortality (RR: 0.78, 95% CI: 0.66\u20130.92;<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><\/a:math><\/jats:inline-formula>\u2009=\u20090.003) and cardiac death (RR: 0.55; 95% CI: 0.31\u20130.96;<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><\/c:math><\/jats:inline-formula>\u2009&lt;\u20090.05), but an increased risk of myocardial infarction (MI) (RR: 1.96; 95%CI: 1.07\u20133.62;<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>P<\/e:mi><\/e:math><\/jats:inline-formula>\u2009&lt;\u20090.05) and repeat revascularization (RR: 7.13; 95% CI: 5.69\u20138.94;<jats:inline-formula><g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><g:mi>P<\/g:mi><\/g:math><\/jats:inline-formula>\u2009&lt;\u20090.00001). There was no statistically significant difference in MACE (RR: 1.11; 95% CI: 0.69\u20131.81;<jats:inline-formula><i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><i:mi>P<\/i:mi><\/i:math><\/jats:inline-formula>\u2009=\u20090.66) between the PCI and CABG groups. Conclusion. In the present meta-analysis comparing PCI and CABG in patients with chronic total occlusion of the coronary arteries, the results indicated that PCI was superior to CABG in reducing all-cause mortality and cardiac death but inferior in decreasing myocardial infarction and repeat revascularization. There was no statistically significant difference in MACE between the two groups.<\/jats:p>","DOI":"10.1155\/2023\/9928347","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T20:50:06Z","timestamp":1699303806000},"page":"1-10","source":"Crossref","is-referenced-by-count":9,"title":["Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting for Chronic Total Occlusion of Coronary Arteries: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-1340","authenticated-orcid":true,"given":"Chenyang","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimov","family":"Kamronbek","sequence":"additional","affiliation":[{"name":"Center for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7808-5370","authenticated-orcid":true,"given":"Siyao","family":"Ni","sequence":"additional","affiliation":[{"name":"Center for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjiu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hangjinqi People\u2019s Hospital, Hangjinqi, Mongolia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3752-0734","authenticated-orcid":true,"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Coronary Heart Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I1A21"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103850"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv450"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.003586"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.06.093"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26354"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy220"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.02.038"},{"issue":"1","key":"9","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.25270\/jic\/20.00299","article-title":"Clinical impact of medical therapy versus revascularization in patients with chronic coronary total occlusions","volume":"33","author":"L.. \u00c1lvarez-Contreras","year":"2021","journal-title":"Journal of Invasive Cardiology"},{"issue":"10","key":"10","first-page":"1380","article-title":"[Long-term outcome of patients undergoing recanalization procedures for chronic total coronary occlusion]","volume":"35","author":"J. 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