{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:48:23Z","timestamp":1769597303639,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obstetrics and Gynecology International"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:p>Introduction and Aim. Sentinel lymph node (SLN) mapping has been developed as an alternative to complete lymphadenectomy for the surgical staging of early-stage, uterine-confined endometrial cancer to reduce the morbidity of lymphadenectomy and has been demonstrated as a safe and feasible alternative. We compare the surgical and oncological outcomes between SLN mapping with routine lymphadenectomy in the surgical staging of early-stage endometrial cancer in our centre. Methods. A retrospective single-centre cohort study of patients with early-stage endometrioid endometrial cancer undergoing staging surgery (total hysterectomy, bilateral salpingo-oophorectomy with\/without pelvic lymph node, and\/or para-aortic lymph node dissection (PLND)) with either SLN mapping or routine lymphadenectomy between July 2017 and December 2018. Results. 203 cases with clinical and radiological International Federation of Gynaecology and Obstetrics (FIGO) stage I endometrioid endometrial cancer were included, out of which 109 cases underwent SLN mapping and 94 cases complete lymphadenectomy. Compared to the PLND group, the SLN group had shorter operative time (129 vs. 162\u2009minutes), less blood loss (100 vs. 300\u2009ml), and decreased length of postoperative hospital stay (3 vs. 4\u2009days) (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The lymph node metastases detection rate was 4.6% and 7.4% for the SLN and PLND groups, respectively (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.389<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). With a median follow-up of 14\u2009months for the SLN and 15\u2009months for the PLND group, the disease-free (DFS) and overall survival (OS) were comparable for both at 13\u2009months (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.538<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.333<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, respectively). Conclusion. SLN mapping has been shown to be an acceptable alternative to routine lymphadenectomy in the surgical staging of early-stage endometrial cancer in our centre, with a comparable lymph node metastases detection rate, DFS and OS, and reduction in operative morbidity. Our results with SLN mapping reproduce comparable outcomes to those reported in the literature.<\/jats:p>","DOI":"10.1155\/2023\/9949604","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T23:06:05Z","timestamp":1697583965000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Comparing Surgical and Oncological Outcomes between Indocyanine Green (ICG) Sentinel Lymph Node Mapping with Routine Lymphadenectomy in the Surgical Staging of Early-Stage Endometrioid Endometrial Cancer"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-0329","authenticated-orcid":true,"given":"Krystal Miao Lin","family":"Koh","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road 229899, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng Yuan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road 229899, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia Hui Xian","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road 229899, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai Loong","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road 229899, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road 229899, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Kuei","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road 229899, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn397"},{"issue":"9658","key":"3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0140-6736(08)61766-3","article-title":"Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study","volume":"373","author":"H. Kitchener","year":"2009","journal-title":"The Lancet"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.09.033"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.03.019"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.05.027"},{"key":"7","article-title":"Uterine neoplasms","author":"Nccn Clinical Practice Guidelines in Oncology","year":"2020"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/ogx.0000000000000467"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12227"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.2019.0070"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.12.385"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901015)60:8+<2035::aid-cncr2820601515>3.0.co;2-8"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1208"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.04.144"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00996.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2013.08.003"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12103"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.11.025"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.09.035"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-002230"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.02.018"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s11805-009-0124-9"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00909.x"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5090-x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.09.011"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200309000-00005"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.12.028"},{"key":"28","article-title":"Sentinel lymph node mapping in endometrial cancer: a systematic review and meta-analysis","author":"J. A. How","year":"2018"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.03.254"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05698-w"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.04.691"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.2020.0191"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.11.003"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.12.017"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2020.5060"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.05.034"}],"container-title":["Obstetrics and Gynecology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ogi\/2023\/9949604.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ogi\/2023\/9949604.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ogi\/2023\/9949604.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T23:06:08Z","timestamp":1697583968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ogi\/2023\/9949604\/"}},"subtitle":[],"editor":[{"given":"Enrique","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":36,"alternative-id":["9949604","9949604"],"URL":"https:\/\/doi.org\/10.1155\/2023\/9949604","relation":{},"ISSN":["1687-9597","1687-9589"],"issn-type":[{"value":"1687-9597","type":"electronic"},{"value":"1687-9589","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,17]]}}}