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We present a case of severe gastrointestinal bleeding as an atypical manifestation of monkeypox infection in a 40-year-old male with HIV. In our case, monkeypox-induced proctocolitis progressed to severe rectal bleeding requiring one unit of packed red blood cells transfusion despite one week of tecovirimat (TPOXX) therapy. So, patients should be educated about the possibility of unusual complications of monkeypox infection, i.e., bleeding in immunocompromised hosts.<\/jats:p>","DOI":"10.1155\/2023\/9981631","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T22:50:07Z","timestamp":1689634207000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Severe Gastrointestinal Hemorrhage due to Monkeypox Virus-Associated Proctocolitis"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-3401","authenticated-orcid":true,"given":"Sobaan","family":"Taj","sequence":"first","affiliation":[{"name":"Department of Medicine, Jersey Shore University Medical Center, Neptune City, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6574-6364","authenticated-orcid":true,"given":"Chris","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Medicine, 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