{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:34:43Z","timestamp":1793295283377,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:p>Introduction. Sleep-disordered breathing (SDB) is common in patients with Prader\u2013Willi Syndrome (PWS). However, the prevalence of SDB varies widely between studies. Early identification of SDB and factors contributing to its incidence is essential, particularly when considering growth hormone (GH) therapy. Objectives. The aims of the study were to describe the prevalence and phenotypes of sleep-disordered breathing (SDB) in patients with Prader\u2013Willi syndrome (PWS) and to determine the effects of age, gender, symptoms, GH therapy and body mass index on SDB severity. Methods. This study was a retrospective chart review of all patients with genetically confirmed Prader\u2013Willi syndrome who underwent diagnostic overnight polysomnography (PSG) in the sleep laboratory at Sidra Medicine. Clinical and PSG data of enrolled patients were collected. Results. We identified 20 patients (nine males, eleven females) with PWS who had overnight sleep polysomnography (PSG) at a median age (IQR) of 5.83 (2.7\u201312) years. The median apnea-hypopnea index (AHI) was 8.55 (IQR 5.8\u201316.9) events\/hour. The median REM-AHI was 27.8 (IQR 15\u201350.6) events\/hour. The median obstructive apnea-hypopnea index (OAHI) was 7.29 (IQR 1.8\u201313.5) events\/hour. The median central apnea-hypopnea index (CAHI) was 1.77 (IQR 0.6\u20134.1) events\/hour. Nineteen patients (95%) demonstrated SDB by polysomnography (PSG) based on AHI \u22651.5 events\/hour. Nine patients (45%) were diagnosed with obstructive sleep apnea (OSA). Three patients (15%) were diagnosed with central sleep apnea (CSA). Seven patients (35%) were diagnosed with mixed sleep apnea. No correlations were observed between AHI and age, gender, BMI, symptoms, or GH therapy. However, REM-AHI was significantly correlated with BMI (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.031<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Conclusion. This study shows a high prevalence of SDB among our patients with PWS. Obstructive sleep apnea was the predominant phenotype. BMI was the only predictor for high REM-AHI. Further studies of large cohorts are warranted to define SDB in PWS and design the appropriate treatment.<\/jats:p>","DOI":"10.1155\/2023\/9992668","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T19:05:06Z","timestamp":1698347106000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence of Sleep-Disordered Breathing in Prader\u2013Willi Syndrome"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-3780","authenticated-orcid":true,"given":"Ahmed","family":"Abushahin","sequence":"first","affiliation":[{"name":"Department of Pediatric Medicine, Sidra Medicine, Doha 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Al-Naimi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Sidra Medicine, Doha 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutasim","family":"Abu-Hasan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Sidra Medicine, Doha 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Arar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Sidra Medicine, Doha 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lina Hayati","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Sidra Medicine, Doha 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonisamy","family":"Belavendra","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Sidra Medicine, Doha 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"Janahi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine, Sidra Medicine, Doha 26999, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2147\/nss.s361518"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/diseases4030023"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-4475"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9938"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9788"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2016.08.002"},{"key":"7","article-title":"The WHO child growth standards","author":"WHO","year":"2006"},{"key":"8","article-title":"American Academy of sleep medicine\u2013 association for sleep clinicians and researchers","author":"Aasm Scoring Manual- American Academy of Sleep 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