{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T22:53:02Z","timestamp":1783291982840,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":249,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Detarium microcarpum<\/jats:italic> (Fabaceae) is a medicinal plant from the traditional pharmacopeia of Niger used against gastrointestinal disorders and dysentery. This study was designed to assess the <jats:italic>in vitro<\/jats:italic> anti\u2010<jats:italic>shigella<\/jats:italic>, antioxidant activities, and oral acute toxicity of extract root barks of <jats:italic>Detarium microcarpum<\/jats:italic>. The crude extracts were prepared by maceration using methanol, ethanol, dichloromethane, water\u2010ethanol (30\/70\u2009v\/v), and methanol\u2010dichloromethane (1\/1\u2009v\/v). The anti\u2010<jats:italic>shigella<\/jats:italic> activity was performed using the microdilution method coupled with the resazurin\u2010based assay. The antioxidant activity was evaluated by the DPPH<jats:sup>\u0387<\/jats:sup> (2, 2\u2010diph\u00e9nyl\u20101\u2010picrylhydrazyl), ABTS 2, 2\u2032\u2010azino\u2010bis (3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid), and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> assays. The oral acute toxicity was assessed following the Organization for Economic Cooperation and Development (OECD) guidelines. The extracts displayed activity against the <jats:italic>Shigella boydii<\/jats:italic> with Minimum Inhibitory Concentrations (MICs) from 500 to 1000\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. The methanolic crude extract of <jats:italic>D. microcarpum<\/jats:italic> shows good antioxidant activity with the radicals DPPH<jats:sup>\u0387<\/jats:sup> and ABTS with inhibitory concentration 50 (IC<jats:sub>50<\/jats:sub>) at 228 and 191\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL, respectively. The lethal dose 50 (LD<jats:sub>50<\/jats:sub>) of extract was up to 2000\u2009mg\/kg of body weight, and no signs of toxicity were observed. These findings supported the use of <jats:italic>Detarium microcarpum<\/jats:italic> in the traditional treatment of gastrointestinal disorders.<\/jats:p>","DOI":"10.1155\/2024\/1330063","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T13:01:56Z","timestamp":1725627716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>In Vitro<\/i> Anti\u2010<i>Shigella<\/i>, Antioxidant Activities, and Oral Acute Toxicity of Organics Extracts from the Root Bark of <i>Detarium microcarpum<\/i> Guill. and Perr."],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3669-0150","authenticated-orcid":false,"given":"Hama Hamadou","family":"Habibou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8785-1292","authenticated-orcid":false,"given":"Mahamane Idi Issa","family":"Abdoulahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikhiri","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_2_9_1_2","unstructured":"DrouetP. 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