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The investigation in this field led to the identification of a large number of genes where methylation features correlated with important clinical and laboratory parameters. Gene\u2010specific analyses investigated methylation in the gene body enhancer regions as well as promoter regions. The findings included genes and proteins involved in key pathways that play central roles in the pathophysiology of the disease. \u03a4he application of these findings beyond the theoretical understanding can not only lead to the creation of prognostic and predictive models and scores but also to the design of novel therapeutic agents. 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