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This pleiotropic cytokine is a classical component of inflammatory soup, secreted by the microglial cell, and promotes a wide range of inflammatory reactions. Aim. In this review, we aimed to provide a culminating and comprehending glimpse into the TNF-\u03b1 in association with the migraine. Method. A systematic literature survey method with a mixture of keywords was utilized to grasp the different elements that represent the association between TNF-\u03b1 and migraine. Discussion. Highlighted the probable involvement of the TNF-\u03b1 with migraine, the complexity of the matter such as activation of NF-KB signaling cascade, autoactivation, sensitization, and increased likelihood of transition cannot be neglected. Being TNF-\u03b1 as a core node, it becomes the factor for linking diseases such as chronic inflammatory disorders, including COVID-19, and also interaction with other genes to develop severe conditions. Conclusion. To this end, TNF-\u03b1 plays a critical role in chronification, and inhibiting its signaling would likely be a crucial strategy for migraine therapy.<\/jats:p>","DOI":"10.1155\/2024\/1377143","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:20:13Z","timestamp":1704327613000},"page":"1-12","source":"Crossref","is-referenced-by-count":21,"title":["Role of TNF-\u03b1 in the Pathogenesis of Migraine"],"prefix":"10.1155","volume":"2024","author":[{"given":"Amrit","family":"Sudershan","sequence":"first","affiliation":[{"name":"Department of Human Genetics, Sri Pratap College Srinagar, Cluster University Srinagar, Srinagar 190001, Jammu and Kashmir, India"},{"name":"Institute of Human Genetics, University of Jammu, Jammu 180006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srishty","family":"Sudershan","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Jammu, Jammu 180006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, University of Jammu, Jammu 180006, Jammu & Kashmir, India"},{"name":"Department of Zoology, University of Jammu, Jammu 180006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Super Specialty Hospital, Jammu 180006, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Panjaliya","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Jammu, Jammu 180006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-6638","authenticated-orcid":true,"given":"Parvinder","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, University of Jammu, Jammu 180006, Jammu & Kashmir, India"},{"name":"Department of Zoology, University of Jammu, Jammu 180006, Jammu & Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.01.08.898239"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1066-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1030940"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1944.7.6.359"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/S00281-018-0676-Y"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-136"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01229-3"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0373-15.2015"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.02.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0116-18.2018"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2014.3352"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.183"},{"issue":"4","key":"13","first-page":"245","article-title":"An overview on immune system and migraine","volume":"11","author":"P. 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