{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:49:27Z","timestamp":1763988567456,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":324,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Infectious Diseases"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Pathogenic <jats:italic>Leptospira<\/jats:italic> species are the source of leptospirosis, a common zoonotic infection that can cause a wide range of clinical manifestations, from minor flu\u2010like symptoms to severe multiorgan failure. We present two peculiar cases of leptospirosis; they highlight the need for clinical awareness to improve patient outcomes and further knowledge of leptospirosis epidemiology and therapy by illuminating the difficulties in diagnosis and treatment. The first case involved a 30\u2010year\u2010old male presented with jaundice. Although he had no history of chronic illnesses, an exhaustive investigation was warranted due to his recent travel history and occupational contact. Laboratory tests revealed significantly increased levels of AST and ALT and positive <jats:italic>Leptospira<\/jats:italic> IgM serology. Remarkably, the patient refuted the traditional theory of leptospirosis transmission by denying direct animal interaction. After starting therapy with dexamethasone initially and adding doxycycline later, the patient\u2019s condition significantly improved; his jaundice resolved and his liver enzyme levels returned to normal. An outpatient follow\u2010up after discharge was advised to assess liver and kidney function. The second case involved an 87\u2010year\u2010old woman with a fever, weakness and hypertension. Investigations revealed hepatosplenomegaly, raising the possibility of hypersplenism. She reported exposure to animals, particularly her dogs in her urban house. Surprisingly, her AST and ALT levels were normal. Lab tests also revealed thrombocytopoenia with normal APTT and prolonged PT. Serological tests indicated positive <jats:italic>Leptospira<\/jats:italic> IgM. Along with intravenous infusions, the patient\u2019s treatment plan comprised dexamethasone, enalapril and ceftriaxone to treat inflammation, hypertension and bacterial infection, respectively. Following a 20\u2010day hospital stay, the patient\u2019s laboratory results and symptoms improved, leading to her discharge. Continuous follow\u2010up recommended to monitor her recovery and prevent recurrence. These case studies emphasise the significance of taking leptospirosis into account when treating patients who do not have normal exposure histories yet present with unusual symptoms.<\/jats:p>","DOI":"10.1155\/2024\/1414417","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T15:18:22Z","timestamp":1732115902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Atypical Cases of Leptospirosis: Insights From Georgia"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1754-2271","authenticated-orcid":false,"given":"Arash Ghani","family":"Dehkordi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9425-7439","authenticated-orcid":false,"given":"Salah Rabea Salah","family":"Al-Tamary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0289-3485","authenticated-orcid":false,"given":"Ashraf Rabea Salah","family":"Al-Tamary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5681-2718","authenticated-orcid":false,"given":"Hamza Rabea Salah","family":"Al-Tamary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2869-1053","authenticated-orcid":false,"given":"Shams Samih Ahmad","family":"Albarari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8688-4932","authenticated-orcid":false,"given":"Alaaldin Mohammad Zeyad","family":"Assad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8334-967X","authenticated-orcid":false,"given":"Ghena Mohammad Othman","family":"Hamdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ia","family":"Mikadze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_17_1_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946201860023"},{"key":"e_1_2_17_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-014-0061-0"},{"key":"e_1_2_17_3_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2021-0784"},{"key":"e_1_2_17_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12091167"},{"key":"e_1_2_17_5_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-662-45059-8_5","volume-title":"Leptospira and Leptospirosis","author":"Haake D. 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