{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:27:48Z","timestamp":1790011668851,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":214,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ211501"],"award-info":[{"award-number":["GJJ211501"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study was to assess the anthelmintic activity of <jats:italic>Lannea kerstingii<\/jats:italic> and <jats:italic>Ficus thonningii<\/jats:italic>, on a nematode model, to promote their use in the Cameroonian pharmacopoeia for the treatment of helminthiases.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> One nematode was used, <jats:italic>Heligmosomoides polygyrus<\/jats:italic>. First, the effect of the extracts on the eggs and larval stages (L1, L2, and L3) of <jats:italic>H. polygyrus<\/jats:italic> was evaluated, 100\u2009<jats:italic>\u03bc<\/jats:italic>L of extract and 100\u2009<jats:italic>\u03bc<\/jats:italic>L of parasite suspension (containing 50 eggs) were mixed in a 96\u2010well microplate. The 96\u2010well microplate was incubated for 20\u2009h at 25\u00b0C in the WMicroTracker which measures the motility of the worms at various concentrations. Finally, docking studies were conducted by using the Glide module in Schrodinger Maestro.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The ethanolic extract of <jats:italic>L. kerstingii<\/jats:italic> with the half maximal inhibitory concentration (IC<jats:sub>50<\/jats:sub>) of 0.1371\u2009mg\/mL produced a higher ovicidal effect than the effect produced by other extracts of these plants. However, with an IC<jats:sub>50<\/jats:sub> of 0.31\u2009mg\/mL, the aqueous extract of <jats:italic>F. thonningii<\/jats:italic> showed the greatest effect on the L2 stage. The aqueous and ethanolic extracts of <jats:italic>L. kerstingii<\/jats:italic> and <jats:italic>F. thonningii<\/jats:italic> inhibited the development of the L3 larvae of <jats:italic>H. polygyrus<\/jats:italic> with a better effect for the ethanolic extracts.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The use of <jats:italic>L. kerstingii<\/jats:italic> and <jats:italic>F. thonningii<\/jats:italic> for the treatment of helminthiasis has been proved in vitro and in silico by this research. However, more research is required, especially on the acute toxicity and in vivo anthelmintic efficacy to validate this scientific investigation.<\/jats:p>","DOI":"10.1155\/2024\/1858154","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T04:34:12Z","timestamp":1722659652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In Vitro and In Silico Anthelmintic Activity of Extracts of <i>Lannea kerstingii<\/i> and <i>Ficus thonningii<\/i> on <i>Heligmosomoides polygyrus<\/i>"],"prefix":"10.1155","volume":"2024","author":[{"given":"Ndjinkeu Ntcheuzing","family":"Serena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3952-0073","authenticated-orcid":false,"given":"Masoud","family":"Besati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-9841","authenticated-orcid":false,"given":"Noumedem Anangmo Christelle","family":"Nadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-8962","authenticated-orcid":false,"given":"Mahdi","family":"Yaghoobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-4296","authenticated-orcid":false,"given":"Yamssi","family":"C\u00e9dric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Ciancia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2599-6310","authenticated-orcid":false,"given":"Ngouyamsa Nsapkain Aboubakar","family":"Sidiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2941-988X","authenticated-orcid":false,"given":"Vincent Khan","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mpoame","family":"Mbida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-4142","authenticated-orcid":false,"given":"Haibo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed2030036"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-019-0550-8"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006269"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000412"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.14194\/ijmbr.128"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001582"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005776"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2022.107937"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415739"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01399-X"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-014-9367-z"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8564163"},{"key":"e_1_2_11_13_2","volume-title":"Quality control methods for medicinal plant materials","author":"World Health Organization","year":"1998"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1703823"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-019-02948-5"},{"key":"e_1_2_11_16_2","first-page":"127","article-title":"Evaluation of antianemic potential compounds of the leaf of a plant in Togo Flora, Lannea kerstingii (Engl. and K. 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