{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:01:10Z","timestamp":1782802870732,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Surgical Oncology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the predictive potency of a novel index combining the pan\u2010immune\u2010inflammatory index and hemoglobin levels (PIV\/Hb) for the prevalence of radiation\u2010induced trismus (RIT) in patients with locally advanced nasopharyngeal cancer (LA\u2010NPC) receiving concurrent chemoradiotherapy (CCRT). <jats:italic>Methods<\/jats:italic>. Data from 228 LA\u2010NPC patients were retrospectively examined. Maximum mouth openings (MMO) were measured to confirm the presence of RIT, defined as MMOs \u226435\u2009mm. Complete blood test results from the first day of CCRT were used to calculate PIV\/Hb levels. A potential relationship between pretreatment PIV\/Hb and the RIT status was evaluated using receiver operating characteristic (ROC) curve analysis. <jats:italic>Results<\/jats:italic>. Post\u2010CCRT RIT was diagnosed in 20.2% of the patients. The ROC curve analysis determined 68.4\u2009g\/dL as the ideal PIV\/Hb cutoff that effectively divided patients into two distinct groups (area under the curve: 94.7%; specificity: 86.4%; sensitivity: 87.4%). RIT was significantly more prevalent in the PIV\/Hb\u2009&gt;\u200968 group than in the PIV\/Hb\u2009&lt;\u200968 group (58.8% vs. 3.8%; <jats:italic>P<\/jats:italic> &lt; 0.001). Multivariate logistic regression analysis showed that a pre\u2010CCRT PIV\u2009&gt;\u200968 was independently associated with significantly higher rates of RIT. <jats:italic>Conclusion<\/jats:italic>. Higher pretreatment levels of the novel PIV\/Hb index predict increased RIT rates following definitive CCRT for LA\u2010NPCs.<\/jats:p>","DOI":"10.1155\/2024\/2124006","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T05:34:29Z","timestamp":1727674469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Index Combining Pan\u2010Immune\u2010Inflammatory Index and Hemoglobin Levels (PIV\/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal 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