{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:51:43Z","timestamp":1773157903223,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":203,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The primary objective of this study is to evaluate the efficacy and safety profile of PreserFlo MicroShunt implantation in the medium\u2010 to long\u2010term follow\u2010up of patients with open\u2010angle glaucoma. The secondary objective is to analyze laser flare meter (LFM) values before and after PreserFlo MicroShunt implantation. <jats:italic>Methods<\/jats:italic>. This prospective, observational, longitudinal single\u2010center study included a total of 62 eyes from 54 patients. A subgroup of 27 eyes (26 patients) reached the 12\u2010month follow\u2010up. Success was defined based on three criteria: criterion A: IOP \u226421\u2009mmHg and \u226520% reduction; criterion B: IOP \u226415\u2009mmHg and \u226525% reduction; and criterion C: IOP \u226412\u2009mmHg and \u226530% reduction. Success was further categorized as complete if achieved without IOP\u2010lowering medications and qualified if achieved with medication administration. Other aspects evaluated included the number of IOP\u2010lowering medications (baseline and postoperative), development of postoperative complications, 5\u2010FU injections or implant revision, and LFM values. <jats:italic>Results<\/jats:italic>. The 12\u2010month follow\u2010up group (27 patients) was composed by 50% males and had a mean age of 75.54\u2009\u00b1\u20099.98\u2009years. Success rates at 12\u2009months were as follows: 78% for criterion A, 56% for criterion B, and 26% for criterion C. Complete success, as defined by criterion A, was achieved by 67% of the patients, 29% achieved qualified success, and one eye (4%) experienced failure. IOP decreased from 25.26\u2009\u00b1\u20091.67\u2009mmHg at baseline to 14.81\u2009\u00b1\u20090.74\u2009mmHg at 12\u2009months. The number of medications decreased from 3.67\u2009\u00b1\u20091.30 at baseline to 0.48\u2009\u00b1\u20090.75 at 12\u2009months. Reported complications were choroidal detachment (11%), hyphema (5%), and athalamia (flat anterior chamber) (2%) 13 eyes (48%) received 5\u2010FU injections, while 7 eyes (26%) underwent implant revision. No significant increase in LFM values was observed. Eyes with a regular postoperative course and IOP \u226415\u2009mmHg showed significantly lower LFM values than patients with unfavorable outcomes (IOP &gt;15\u2009mmHg, development of complications, 5\u2010FU injection, or implant revision). <jats:italic>Conclusions<\/jats:italic>. PreserFlo MicroShunt showed a significant reduction in IOP and a decrease in the number of IOP\u2010lowering medications. Complications occurred at a modest frequency. The implant provides a minimally invasive approach with no significant increases in LFM values postoperatively. Higher LFM values correlate with unfavorable postoperative outcomes.<\/jats:p>","DOI":"10.1155\/2024\/2447721","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T05:05:01Z","timestamp":1721711101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of PreserFlo MicroShunt Implantation and Its Effects on Intraocular Inflammation through Laser Flare Photometry"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-9219","authenticated-orcid":false,"given":"Carlo","family":"Cagini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Boni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Bonifazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-4627","authenticated-orcid":false,"given":"Daniela","family":"Fruttini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6535-9124","authenticated-orcid":false,"given":"Francesco","family":"Della Lena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.67"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S80490"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33525"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20110603-01"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-015-0134-8"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/vision6010012"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-009-9310-2"},{"key":"e_1_2_7_8_2","volume-title":"Guidelines on Design and Reporting of Glaucoma Surgical Trials","author":"Shaarawy T. 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