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While the overall characteristics of these cases were similar to those in previous reports, we noticed that all cases were negative for thyroid autoantibodies and an autopsy in one of the cases exhibited end\u2010stage thyroiditis. During a systematic review of cases from 1999 to 2022, we also noticed that a significant proportion of myxedema coma was caused by seronegative primary hypothyroidism especially in Japan.<\/jats:p>","DOI":"10.1155\/2024\/2524019","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:33:27Z","timestamp":1728905607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-9848","authenticated-orcid":false,"given":"Yosuke","family":"Okuno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9365-5561","authenticated-orcid":false,"given":"Kosuke","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6798-8213","authenticated-orcid":false,"given":"Yuri","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-6558","authenticated-orcid":false,"given":"Tomoaki","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6289-3778","authenticated-orcid":false,"given":"Atsunori","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iichiro","family":"Shimomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.je.2016.04.002"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01884-6"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1800347"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP13460.OR"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021194"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-3-661"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-65-5-987"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ21-0720"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgf2.267"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.2169\/naika.101.1066"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm.2020.02.26"},{"key":"e_1_2_13_12_2","first-page":"268","article-title":"Myxedema Coma with Reversible Cardiopulmonary Failure: A Rare Entity in 21st Century","volume":"10","author":"Dhakal P.","year":"2015","journal-title":"Maedica"},{"key":"e_1_2_13_13_2","first-page":"2485","article-title":"Myxedema Coma: Diagnosis and Treatment","volume":"62","author":"Wall C. 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