{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:46:45Z","timestamp":1767890805703,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["HLBKJ202023"],"award-info":[{"award-number":["HLBKJ202023"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2024,3,2]]},"abstract":"<jats:p>Background. Premature infants are exposed to numerous stressors in neonatal intensive care unit (NICU) during a crucial period for brain development; this period exerts long-term influences on cognitive and behavioral development. Aims. To evaluate the effect of NICU-related stress on neonatal rat pups and explore the effect of Chinese medicine treatment (CMT). Methods. Sixty male rat pups were randomly assigned to three groups: the control group, the NICU group (NICU-related stress), and the CMT group (NICU-related stress plus CMT). All stressors and interventions were administered from 0 to 7 days after birth. Body weight, serum corticosterone levels, and behavior in the open field (OF) test, elevated plus maze (EPM) test, sucrose preference test, and Morris water maze (MWM) test were recorded, and blood samples were collected at five different time points (T0, T1, T2, T3, and T4). Results. The body weights of rats in the CMT and control groups were heavier than those in the NICU group in both early life and adulthood (<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><a:mo>&lt;<\/a:mo><a:mn>0.05<\/a:mn><\/a:math><\/jats:inline-formula>). Serum corticosterone levels significantly differed with time (except T0 vs. T1 and T3 vs. T4) but did not significantly differ among the three groups (<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>F<\/c:mi><c:mo>=<\/c:mo><c:mn>0.441<\/c:mn><\/c:math><\/jats:inline-formula>, <jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>P<\/e:mi><e:mo>=<\/e:mo><e:mn>0.894<\/e:mn><\/e:math><\/jats:inline-formula>). Regardless of age, spatial memory and anxiety-like and depression-like behavior did not differ among the three groups. Conclusion. NICU-related stress exerted a long-term effect on rat growth and development but did not affect spatial memory, anxiety-like behavior, depression-like behavior, or serum corticosterone levels. CMT alleviated the impact of NICU-related stress on rats and promoted the growth and development of neonatal rats.<\/jats:p>","DOI":"10.1155\/2024\/2733884","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T18:05:09Z","timestamp":1709402709000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["Alleviating Neonatal Intensive Care Unit Stress: A Chinese Medicine Approach in Neonatal Rats"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-4418","authenticated-orcid":true,"given":"Yingxin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiujuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-8190","authenticated-orcid":true,"given":"Qiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Preterm birth","author":"World health organization","year":"2018"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2018.12.002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/srep39159"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.001"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/cdev.12492"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/dev.22212"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12175"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2006.12.013"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.00715"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21941"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2090-6"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579411000484"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00722"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2006"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.10.016"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.02.007"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076702"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1863"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.117.5.883"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2014.08.005"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00338-2"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(02)00611-9"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.11.049"},{"key":"25","volume-title":"Epigenetic mechanism underlying Chinese medicine treating fetus injuries due to prenatal PTSD and fear on pregnant SD rat","author":"H. Zhang","year":"2017"},{"key":"26","volume-title":"Handbook of Practical Animal Acupuncture [M]","author":"Y. Hu","year":"2014"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90330-6"},{"issue":"8","key":"28","first-page":"1237","article-title":"Evaluation of application effect of point massage in neonatal touching","volume":"27","author":"Y. Jin","year":"2012","journal-title":"Zhongguo Fuyou Baojian"},{"issue":"6","key":"29","first-page":"497","article-title":"Effect of electroacupuncture at \"Zusanli\"(ST 36) on the expression of ghrelin\/cAMP\/PKA in the jejunum in rats with spleen qi deficiency syndrome","volume":"41","author":"R. L. Yong","year":"2016","journal-title":"Zhen Ci Yan Jiu"},{"key":"30","volume-title":"The Effect of Five-Element Music Therapy Combined with Kangaroo Care on the Physical and Neurodevelopment of Preterm Infants","author":"Q. Zheng","year":"2021"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00406-0"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.11.039"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1159\/000351121"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.014"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20511"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22129"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2024\/2733884.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2024\/2733884.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2024\/2733884.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T18:05:14Z","timestamp":1709402714000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2024\/2733884\/"}},"subtitle":[],"editor":[{"given":"Abdelwahab","family":"Omri","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,2]]},"references-count":36,"alternative-id":["2733884","2733884"],"URL":"https:\/\/doi.org\/10.1155\/2024\/2733884","relation":{},"ISSN":["2314-6141","2314-6133"],"issn-type":[{"value":"2314-6141","type":"electronic"},{"value":"2314-6133","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,2]]}}}