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Previous reports demonstrated that <jats:italic>\u03b2<\/jats:italic>\u2010glucan was widely investigated as a potent immunomodulators to stimulate innate and adaptive immune responses, which indicated that it could be recommended as an effective adjuvant in immunotherapy. However, the detailed effects of <jats:italic>\u03b2<\/jats:italic>\u2010glucan on neonatal immunity are still largely unknown. Here, we found that <jats:italic>\u03b2<\/jats:italic>\u2010glucan did not affect the frequencies and numbers of myeloid cells in the spleen and bone marrow from neonates. Functional assay revealed that <jats:italic>\u03b2<\/jats:italic>\u2010glucan from neonates compromised the immunosuppressive function of immature myeloid cells, which were myeloid\u2010derived suppressor cells (MDSCs). Flow cytometry or gene expression analysis revealed that <jats:italic>\u03b2<\/jats:italic>\u2010glucan\u2010derived polymorphonuclear (PMN)\u2010MDSCs produced lower level of reactive oxygen species (ROS) and arginase\u20101 (<jats:italic>Arg1<\/jats:italic>) in neonatal mice. Furthermore, <jats:italic>\u03b2<\/jats:italic>\u2010glucan administration significantly decreased the frequency and ROS level of PMN\u2010MDSCs in vitro. These observations suggest that <jats:italic>\u03b2<\/jats:italic>\u2010glucan facilitates the maturation of myeloid cells in early life, which may contribute to its beneficial effects against immune disorders later in life.<\/jats:p>","DOI":"10.1155\/2024\/2765001","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T18:05:09Z","timestamp":1715709909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>\u03b2<\/i>\u2010Glucan Subverts the Function of Myeloid Cells in 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