{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:15:45Z","timestamp":1773706545788,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":288,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Medicine International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Wound or injury can be defined as partial or complete separation of the skin, while the healing of the wounds is defined as the sequences of processes by which the skin heals and returns to its normal appearance. This study aims to evaluate the efficacy of <jats:italic>Laurus nobilis<\/jats:italic> leaf extracts on the healing of open wounds in rabbits. Twenty\u2010four healthy rabbits were used, divided randomly into control and treated groups, each consisting of 12 rabbits. The rabbits were caused to experience circular wound defects (2.5\u2009cm) in diameter. All animals in the control (C) group were left without treatment while those in the <jats:italic>Laurus nobilis<\/jats:italic> leaf extract group were treated with drops of the aqueous extract of <jats:italic>Laurus nobilis<\/jats:italic> in a dose of 200\u2009mg\/kg per day for 20\u2009days. The results of macroscopic observation revealed that all animals in both groups showed equitable viability and good appetite, no mortality occurred, and no signs of infection. In the group with the <jats:italic>Laurus nobilis<\/jats:italic> extract, we noticed a significant improvement in wound\u2010healing activity and a reduction in the wound area at <jats:italic>p<\/jats:italic> \u2264 0.05 compared with the C group. Histopathological results at the end of the study show that the thick epidermal layer covers a mass of granulation with congested blood vessels and the dermis transforms into a denser layer gradually due to the improvements of the cellularity in the C group and also revealed a well\u2010formed skin appearance, widespread of collagen, and fibrosis within the dermis with an appearance near the normal dermis in the group treated with <jats:italic>Laurus nobilis<\/jats:italic> leaf extract. In conclusion, the results confirmed that using <jats:italic>Laurus nobilis<\/jats:italic> methanolic extract solution in a daily dose of 200\u2009mg\/kg promotes healing of open wounds in rabbits.<\/jats:p>","DOI":"10.1155\/2024\/2889480","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T11:33:23Z","timestamp":1728992003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of <i>Laurus nobilis<\/i> Leaf Extract on Healing of Experimentally Induced Wounds in Rabbits"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-8498","authenticated-orcid":false,"given":"Omar Tariq","family":"Hammoodi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-250X","authenticated-orcid":false,"given":"Majid A.","family":"Alkhilani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-9560","authenticated-orcid":false,"given":"Wissam Abdullah","family":"Alhayani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-2368","authenticated-orcid":false,"given":"Waleed","family":"Al-Nuaimy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1035-4051","authenticated-orcid":false,"given":"Ali A.","family":"Tala\u2019a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21210"},{"key":"e_1_2_10_2_2","article-title":"Wound healing and Its Importance\u2014A Review","author":"Shankar M.","year":"2014","journal-title":"Der Pharmacologia Sinica"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.2478\/s11536-009-0081-y"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b03868"},{"key":"e_1_2_10_5_2","article-title":"Red Jujube-Incorporated Gelatin Methacryloyl (GelMA) Hydrogels With Anti-Oxidation and Immunoregulation Activity for Wound Healing","author":"Jun H.","year":"2019","journal-title":"Journal of Biomedical Nanotechnology"},{"key":"e_1_2_10_6_2","volume-title":"Beneficial Effects of Leaf Extracts of Lycoperscon Esculentum on Wound Healing in Rats","author":"Zamide E. 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