{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:44Z","timestamp":1785445304077,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Sterify S.r.l."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Periodontal disease is a common infectious disease that leads to the destruction of tooth\u2010supporting structures. Current treatments, such as scaling and root planing (SRP), have limitations in deep and complex pockets, and antibiotic use carries the risk of resistance. Sterify Gel, a medical device composed of polyvinyl polymers, hydroxytyrosol, nisin, and magnesium ascorbyl phosphate, offers a new approach to periodontal care. This study aims to evaluate the safety and efficacy of Sterify Gel as an adjunctive treatment to SRP in promoting the healing of periodontal pockets.\n                    <jats:italic>Methods<\/jats:italic>\n                    . The study includes 34 patients with moderate to advanced chronic periodontal disease. Randomization assigned one site for SRP alone (control) and the other site for SRP with Sterify Gel (treatment). Periodontal parameters were evaluated at baseline, 1, 2, and 3 months after treatment bacterial contamination was assessed through quantitative PCR at baseline and 3 months after treatment. Statistical analysis was conducted using ANOVA and Wilcoxon test.\n                    <jats:italic>Results<\/jats:italic>\n                    . Treatment with Sterify Gel and SRP demonstrated significant improvements in pocket depth, gingival recession, and clinical attachment level compared with SRP alone. Bleeding and plaque indexes, pain perception, tooth mobility, and furcations showed no significant differences between the two groups. The treatment group showed a reduction in bacterial contamination at 3 months.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Sterify Gel in combination with SRP shows the potential for improving periodontal health by promoting healing and reducing periodontal pockets. It may offer benefits in preventing bacterial recolonization and reducing reliance on antibiotics.\n                  <\/jats:p>","DOI":"10.1155\/2024\/3113479","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T11:35:07Z","timestamp":1704368107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Sterify Gel as an Adjunctive Treatment to Scaling and Root Planing in Promoting Healing of Periodontal Pockets: A Split\u2010Mouth Randomized Controlled Trial"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-7765","authenticated-orcid":false,"given":"Luca","family":"Levrini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6541-1014","authenticated-orcid":false,"given":"Michela","family":"Rossini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Truppello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-4880","authenticated-orcid":false,"given":"Simone","family":"Sevi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3823-2175","authenticated-orcid":false,"given":"Enrico","family":"Fiorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-3079","authenticated-orcid":false,"given":"Stefano","family":"Benedicenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-6471","authenticated-orcid":false,"given":"Claudio","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-470X","authenticated-orcid":false,"given":"Davide","family":"Farronato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2008.02.003"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00243.x"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12945"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01146.x"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027001030.x"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.34172\/JLMS.2021.15"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.9.s1.8.x"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.115"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/d0bm01160f"},{"key":"e_1_2_12_11_2","volume-title":"Tackling Drug-Resistant Infections Globally: Final Report and Recommendations","author":"O\u2019Neill J.","year":"2016"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12146"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012910.x"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027006447.x"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-011-0630-z"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-1021-0"},{"key":"e_1_2_12_17_2","volume-title":"Olive Oil\u2014Constituents, Quality, Health Properties and Bioconversions","author":"Fern\u00e1ndez-Bola\u00f1os J. 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