{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:18:19Z","timestamp":1757701099794,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kenyatta National Hospital Research Grant","award":["KNH\/R&P\/23I\/3\/9"],"award-info":[{"award-number":["KNH\/R&P\/23I\/3\/9"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Multiple myeloma (MM) is a chronic B\u2010cell malignancy that involves proliferation of neoplastic clonal plasma cells in the bone marrow with circulating monoclonal immunoglobulins or constituent chains in serum or urine or both. It is a rare cancer with a lifetime risk of 0.76% and an age\u2010adjusted incidence rate of 2.5\u20137.2 per 100,000 in high\u2010income countries. There is a paucity of local data on the morbidity and treatment of MM. <jats:italic>Methods<\/jats:italic>. This was a single\u2010centre descriptive retrospective study at the Kenyatta National Hospital (KNH). The study population included inpatients and outpatients with a documented diagnosis of MM managed between 1<jats:sup>st<\/jats:sup> January 2014 and 31<jats:sup>st<\/jats:sup> December 2018. Demographic data, pathology reports, laboratory results, and clinical findings were transcribed and uploaded to a database, and data analysis was done using Stata 16\u00ae software. <jats:italic>Results<\/jats:italic>. A total of 207 patient files were reviewed. The median age at presentation was 60\u2009years with a slight male preponderance. Bone pain was the predominant complaint in 59% (139\/207) of patients, with 17% of patients presenting with paraparesis or paraplegia. For patients who underwent imaging, osteolytic bone lesions were identified in 90.6% (126\/139). Anaemia was present in 71% (147\/207) patients, hypercalcemia in 55.4%, and renal dysfunction in 38.2%. There were 25 different treatment regimens prescribed, with 13 patients (7%) being on bortezomib\u2010based triplet therapy. <jats:italic>Conclusions<\/jats:italic>. MM in KNH is a disease of the middle aged, affecting men and women almost equally and presenting mainly with bone pain and anaemia. Although there seems to be a general improvement in diagnosis and care, access to novel and less toxic agents for treatment is still wanting.<\/jats:p>","DOI":"10.1155\/2024\/3208717","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T23:35:07Z","timestamp":1707780907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Profile and Treatment of Multiple Myeloma at a Tertiary Hospital in Kenya: A Five\u2010Year Retrospective Review"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-3136","authenticated-orcid":false,"given":"Wanjiku","family":"Gichuru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A. 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