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We present a case of CD5\u2010negative classic MCL that progressed to an EBV\u2009+\u2009pleomorphic MCL six years after the initial diagnosis. Molecular studies confirmed the same clonal origin. To the best of our knowledge, the EBV\u2010positive transformation of CD5\u2010negative MCL into a pleomorphic variant has rarely been reported, and its recognition is important for the diagnosis and the management of patients with MCL.<\/jats:p>","DOI":"10.1155\/2024\/3267739","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T15:13:49Z","timestamp":1717686829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["EBV\u2010Positive Pleomorphic Variant Transformation of CD5\u2010Negative Mantle Cell Lymphoma: A Rare Case Report and Literature Review"],"prefix":"10.1155","volume":"2024","author":[{"given":"Amy","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel 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