{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:55:22Z","timestamp":1777697722203,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":245,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00210403"],"award-info":[{"award-number":["RS-2023-00210403"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2022R1C1C2003637"],"award-info":[{"award-number":["2022R1C1C2003637"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2022R1A5A1033624"],"award-info":[{"award-number":["2022R1A5A1033624"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00301938"],"award-info":[{"award-number":["RS-2023-00301938"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Complexity"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Infectious diseases pose a significant threat to global health, necessitating the development of effective vaccination strategies. This study examines the dynamics of viral infections and immune responses, with a particular focus on the roles of antibodies and CD8+ T cells induced by vaccination. Through a mathematical model, we explore the intricate interactions between host cells and viruses to assess the impact of vaccination on viral replication. Our findings align with experimental results, demonstrating that vaccination substantially enhances immune responses and reduces viral replication. The contributions of both antibody and CD8+ T cell responses are shown to be vital for achieving optimal vaccine efficacy. The model\u2019s predictions, validated against experimental observations, emphasize the need to incorporate mechanisms that induce robust immune responses in vaccine design. This study underscores the critical role of mathematical modeling in understanding immune dynamics and in refining vaccination strategies to develop more effective treatments against viral infections.<\/jats:p>","DOI":"10.1155\/2024\/3357763","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T12:21:01Z","timestamp":1725279661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Immune Responses through Dynamic Modeling of Cell\u2010Immune Interactions in Viral Infection and Vaccination"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6626-316X","authenticated-orcid":false,"given":"Kwang Su","family":"Kim","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-5124","authenticated-orcid":false,"given":"Il Hyo","family":"Jung","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-8176","authenticated-orcid":false,"given":"Jong Hyuk","family":"Byun","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"e_1_2_10_2_2","unstructured":"FDA Pfizer-biontech COVID-19 vaccine (BNT162 PF-07302048) vaccines and related biological products advisory committee briefing document meeting date: 10 December 2020 2020."},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2003138117"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307140101"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008140"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2034577"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2027906"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2022483"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2035389"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6284"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00480-0"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.01.020"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.01.036"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12020102"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idm.2020.03.001"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.3386\/w26867"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bsheal.2020.03.004"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2020.108438"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(20)30232-2"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25866"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(20)30113-4"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10867-022-09617-9"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chaos.2021.110952"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2003.08.055"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.2144\/99261rv01"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008x(88)90051-8"},{"key":"e_1_2_10_27_2","first-page":"2020","article-title":"BNT162b2 induces SARS-CoV-2-neutralising antibodies and T cells in humans","author":"Sahin U.","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.8.3.628-631.2001"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601877"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00177"},{"key":"e_1_2_10_31_2","article-title":"RNA-based COVID-19 vaccine BNT162b2 selected for a pivotal efficacy study","volume":"2020","author":"Walsh E. E.","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2639-4"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00165"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813390106"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2026920"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00024-07"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-011-0043-6"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.02.002"}],"container-title":["Complexity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/3357763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T12:21:12Z","timestamp":1725279672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/3357763"}},"subtitle":[],"editor":[{"given":"Siew Ann","family":"Cheong","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/3357763"],"URL":"https:\/\/doi.org\/10.1155\/2024\/3357763","archive":["Portico"],"relation":{},"ISSN":["1076-2787","1099-0526"],"issn-type":[{"value":"1076-2787","type":"print"},{"value":"1099-0526","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3357763"}}