{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:05:21Z","timestamp":1777284321761,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":297,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018375","name":"Fondation FondaMental","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-IDEX-0004-02"],"award-info":[{"award-number":["ANR-11-IDEX-0004-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-COHO-10-01"],"award-info":[{"award-number":["ANR-10-COHO-10-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Bipolar disorders (BD) are characterized by mood symptoms that can worsen medication side effects. We aimed to study the association between residual mood signs and self\u2010reported side effects in the euthymic phase of BD.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We assessed residual mood signs using the Montgomery\u2013Asberg Depression Rating scale (MADRS) and Young Mania Rating scale (YMRS) and self\u2010reported side effects using the Patient\u2010Rated Inventory of Side Effects (PRISE\u2010M) for 880 males and 1369 females with BD. We conducted a network analysis to test the associations between 52 items of the three scales for males and females separately. We then identified clusters of nodes that fit the networks well.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> We report only positive associations between residual mood signs and side effects. An elevated mood (YMRS) in females and increased energy (YMRS) in males were central nodes, strongly influencing the development of additional mood symptoms and side effects. Furthermore, we identified three clusters of nodes in both sexes: (1) a \u201cmood cluster\u201d, including most YMRS and MADRS items and the PRISE\u2010M items evaluating sedation, sleep, and restlessness, (2) a cluster of nonsexual side effects (mostly PRISE\u2010M items), and (3) a cluster of sexual side effects. In both sexes, we identified bridge nodes that may favor the communication between mood and side effects, namely palpitations (PRISE\u2010M) and agitation (PRISE\u2010M).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results justify the particular attention of practitioners to monitor elevated moods or increased energy to try to reduce self\u2010reported side effects and other residual mood symptoms in the euthymic phase of BD. Our findings suggest that clinicians could consider patient\u2010reported loss of energy, difficulty in falling asleep, and restlessness as mood symptoms rather than medications\u2019 side effects. Palpitations and agitation may contribute to the development of additional mood symptoms or somatic complaints.<\/jats:p>","DOI":"10.1155\/2024\/3375145","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T09:03:43Z","timestamp":1729760623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Association Between Residual Mood Symptoms and Self\u2010Reported Side Effects in the Euthymic Phase of Bipolar Disorders: A Cross\u2010Sectional Network Analysis"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1396-470X","authenticated-orcid":false,"given":"Nathan","family":"Vidal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Brunet-Gouet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-6715","authenticated-orcid":false,"given":"Sol\u00e8ne","family":"Frileux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Aubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Belzeaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6519-8586","authenticated-orcid":false,"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"D\u2019Amato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Dubertret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Etain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Gard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Haffen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Januel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Leboyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Lefrere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Michel","family":"Llorca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeline","family":"Marlinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Oli\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea","family":"Polosan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymund","family":"Schwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Walter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The FACE-BD (FondaMental Academic Centers of Expertise for Bipolar Disorders) group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Passerieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-4189","authenticated-orcid":false,"given":"Paul","family":"Roux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31544-0"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/psychiatry.IndianJPsychiatry_760_19"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.09.076"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(14)70007-2"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/24009.9873"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.09m00883yel"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2022.9"},{"key":"e_1_2_12_8_2","first-page":"104","article-title":"Lithium Side-Effects and Predictors of Hypothyroidism in Patients with Bipolar Disorder: Sex Differences","volume":"27","author":"Henry C.","year":"2002","journal-title":"Journal of Psychiatry & Neuroscience: JPN"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000185423.15891.02"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18465"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.09.102"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/00332941231213649"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000497425"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X09991567"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-021-01342-z"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1745691617705892"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socnet.2010.03.006"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-016-1319-z"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000442001"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141420"},{"key":"e_1_2_12_21_2","first-page":"412","article-title":"Association of Symptom Network Structure With the Course of Depression\u201d: Correction","volume":"73","author":"van Borkulo C.","year":"2016","journal-title":"JAMA Psychiatry"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-017-0910-x"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717001258"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24224-2"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2016.09.002"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_12_27_2","volume-title":"Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II)","author":"First M. B.","year":"1997"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2009.00726.x"},{"key":"e_1_2_12_29_2","first-page":"28","article-title":"The Clinical Global Impressions Scale: Applying a Research Tool in Clinical Practice","volume":"4","author":"Busner J.","year":"2007","journal-title":"Psychiatry Edgmont Pa Townsh"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-016-0007-6"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(03)00112-0"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.795666"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.06.037"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.040"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv037"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-015-0029-9"},{"key":"e_1_2_12_39_2","unstructured":"HaslbeckJ. M. B.andWaldorpL. J. Structure Estimation for Mixed Graphical Models in High Dimensional Data 2016."},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1037\/met0000471"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00055-w"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-017-0862-1"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1140\/epjb\/e2013-40829-0"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159161"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2019.1614898"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790340082012"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08050746"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12603"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2010.06.010"},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852916000614"},{"key":"e_1_2_12_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12140"},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2012.01882.x"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.6.956"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.110.081992"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90118-4"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.45512"},{"key":"e_1_2_12_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02291.x"},{"key":"e_1_2_12_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1987.tb10566.x"},{"key":"e_1_2_12_59_2","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1128"}],"container-title":["Depression and Anxiety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/3375145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T09:03:49Z","timestamp":1729760629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/3375145"}},"subtitle":[],"editor":[{"given":"Francesco","family":"Bartoli","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/3375145"],"URL":"https:\/\/doi.org\/10.1155\/2024\/3375145","archive":["Portico"],"relation":{},"ISSN":["1091-4269","1520-6394"],"issn-type":[{"value":"1091-4269","type":"print"},{"value":"1520-6394","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3375145"}}