{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:39:16Z","timestamp":1787683156174,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017268","name":"Berlin Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Projekt DEAL"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:p>Systemic mastocytosis is defined by the clonal proliferation of abnormal mast cells. The clinical course can range from indolent forms with normal life expectancy to advanced mast cell leukemia with dismal prognosis. An association with other diseases, including myeloproliferative neoplasia, has been described. We present a case of a 75-year patient with a history of cutaneous mastocytosis who was diagnosed with mast cell leukemia more than 9\u2009years ago and did not receive treatment. The patient presented to our clinic with acute kidney failure because of renal extramedullary hematopoiesis. Bone marrow histopathology revealed extensive fibrosis and 50% infiltration by mast cells with a c-KIT D816V mutation. No mutations supporting primary myelofibrosis were identified. Treatment with midostaurin was started, and the patient was discharged after improvement of renal function. Here, we discuss diagnostic challenges between different forms of mast cell leukemia and overlaps with other hematological malignancies.<\/jats:p>","DOI":"10.1155\/2024\/3502887","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T17:20:21Z","timestamp":1704302421000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Renal Extramedullary Hematopoiesis in Mast Cell Leukemia with Bone Marrow Fibrosis"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-7977","authenticated-orcid":true,"given":"Damian T.","family":"Rieke","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin, Hindenburgdamm 30, Berlin 12203, Germany"},{"name":"Berlin Institute of Health (BIH) at Charit\u00e9, Universit\u00e4tsmedizin Berlin, Anna-Louisa-Karsch-Stra\u00dfe 2, Berlin 10178, 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