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The dairy farm environment may serve as a hotspot and reservoir for exchanging and spreading ARGs, but studies are scarce. Here, we investigated and characterized the extended\u2010spectrum <jats:italic>\u03b2<\/jats:italic>\u2010lactamase producing <jats:italic>Escherichia coli<\/jats:italic> strains recovered from the dairy farm environment co\u2010harboring <jats:italic>bla<\/jats:italic><jats:sub>OXA\u22121<\/jats:sub>, <jats:italic>catB3<\/jats:italic>, and <jats:italic>arr-3<\/jats:italic> genes. The isolates were identified and characterized by PCR, antimicrobial susceptibility testing, conjugation assay, whole genome sequencing (WGS), and multiple bioinformatics tools. Seven <jats:italic>E. coli<\/jats:italic> strains co\u2010harboring <jats:italic>bla<\/jats:italic><jats:sub>OXA\u22121<\/jats:sub>, <jats:italic>catB3<\/jats:italic>, and <jats:italic>arr-3<\/jats:italic> genes were identified which belonged to distinct sequence types (STs) and carried diverse plasmid replicon types. The conjugation assay revealed a successful transfer of <jats:italic>bla<\/jats:italic><jats:sub>OXA\u22121<\/jats:sub>, <jats:italic>catB3<\/jats:italic>, and <jats:italic>arr-3<\/jats:italic> genes into the recipient <jats:italic>E. coli<\/jats:italic> J53 with a co\u2010conjugation frequency ranging from (2.25\u2009\u00b1\u20090.3)\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup> to (3.85\u2009\u00b1\u20090.3)\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>. Bioinformatics analysis of WGS revealed the diversity of acquired ARGs, conferring resistance to aminoglycosides, beta\u2010lactams, quinolones, tetracyclines, macrolides, trimethoprim\u2013sulfamethoxazole, phosphonic, phenicol, and rifamycin. The genetic environment analysis showed that <jats:italic>aac<\/jats:italic>(<jats:italic>6<jats:sup>\u2032<\/jats:sup><\/jats:italic>)\u2010<jats:italic>Ib-cr-bla<\/jats:italic><jats:sub>OXA\u22121<\/jats:sub>\u2010<jats:italic>catB3-arr-3-qacE1-sul1<\/jats:italic> was the common genetic backbone among the seven <jats:italic>E. coli<\/jats:italic> strains. Among the mobile genetic elements, insertion sequences were the predominant elements as compared to transposons. The phylogenetic analysis demonstrated a close relationship between the <jats:italic>E. coli<\/jats:italic> of this study and other strains of human\u2013animal\u2010environment origin retrieved from the NCBI database. This study presented the whole genome\u2010based characterization of <jats:italic>E. coli<\/jats:italic> strains carrying the <jats:italic>bla<\/jats:italic><jats:sub>OXA\u22121<\/jats:sub>\u2010<jats:italic>catB3-arr-3<\/jats:italic> genes. It provided evidence that the dairy environment may harbor a variety of ARGs and act as a potential reservoir for their spread in the ecosystem. The results recommend the routine surveillance of ARGs carrying bacteria in dairy environments and the need for additional studies to understand the dissemination mechanism within One Health perspective to prevent their further spread.<\/jats:p>","DOI":"10.1155\/2024\/3526395","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T07:49:54Z","timestamp":1728632994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genomic Characterization of Extended\u2010Spectrum <i>\u03b2<\/i>\u2010Lactamase (ESBL) Producing <i>E. coli<\/i> Harboring <i>bla<\/i><sub>OXA\u22121<\/sub>\u2010<i>catB3-arr-3<\/i> Genes Isolated From Dairy Farm Environment in China"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-1840","authenticated-orcid":false,"given":"Muhammad","family":"Shoaib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-954X","authenticated-orcid":false,"given":"Minjia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7454-1323","authenticated-orcid":false,"given":"Furqan","family":"Awan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7618-3948","authenticated-orcid":false,"given":"Amjad Islam","family":"Aqib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9736-7377","authenticated-orcid":false,"given":"Ruochen","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-6771","authenticated-orcid":false,"given":"Saad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-5059","authenticated-orcid":false,"given":"Shengyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-0761","authenticated-orcid":false,"given":"Ruofeng","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-5855","authenticated-orcid":false,"given":"Wanxia","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"e_1_2_12_1_2","unstructured":"OrganizationW. 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