{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:58:06Z","timestamp":1784879886100,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":160,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. <jats:italic>Helicobacter pylori<\/jats:italic> are the principal causative factor in the etiological factors of chronic, active, or type B gastritis; peptic and duodenal ulcers; stomach carcinoma; and epithelial tissue lymphoid malignancies. It infects more than half of the population worldwide. To reduce <jats:italic>H. pylori<\/jats:italic> production, pharmacological therapy of <jats:italic>H. pylori<\/jats:italic> diseases typically involves using threefold treatment methods. However, as a result of such therapy, antimicrobial resistance is commonly developed. Alternative therapeutics for <jats:italic>H. pylori<\/jats:italic> diseases are thus of particular interest. <jats:italic>Methods<\/jats:italic>. Thyme essential oils (EOs) obtained from <jats:italic>T. caramanicus<\/jats:italic> Jalas plants in Iran were tested for antibacterial activity against <jats:italic>H. pylori<\/jats:italic> obtained from 320 poultry specimens in this investigation. Antibacterial activity was measured using inhibition zones, minimum inhibitory concentrations (MICs), and minimum bactericidal concentrations (MBCs). The impact of <jats:italic>T. caramanicus<\/jats:italic> Jalas essential oils on <jats:italic>H. pylori<\/jats:italic> isolate <jats:italic>cagA<\/jats:italic>, <jats:italic>vacA<\/jats:italic>, and <jats:italic>babA2<\/jats:italic> gene expression was evaluated using a quantitative real\u2010time PCR method (<jats:italic>p<\/jats:italic> &lt; 0.05). <jats:italic>Results<\/jats:italic>. The chemical content of these EOs varied significantly according to chromatographic examination. Thymol, carvacrol, and terpinene\u20104\u2010ol are the most abundant components in these EOs. <jats:italic>H. pylori<\/jats:italic> was recognized as a <jats:italic>Helicobacter<\/jats:italic> species with a 175\u2010bp PCR product of 16S rRNA in 20\/20 (100%). According to PCR results, all 20 (100%) isolates belonged to <jats:italic>H. pylori<\/jats:italic>. The EOs inhibited <jats:italic>H. pylori<\/jats:italic> in a dose\u2010dependent manner, with <jats:italic>T. caramanicus<\/jats:italic> Jalas being the most effective, followed by pterygium EOs in decreasing order. At 8\u2009mg\/mL of <jats:italic>T. caramanicus<\/jats:italic> Jalas EOs, IZs against <jats:italic>H. pylori<\/jats:italic> were 27.4\u2009\u00b1\u20090.42\u2009mm, and at 8\u2009mg\/mL of pterygium, IZs against <jats:italic>H. pylori<\/jats:italic> were 1\u2009\u00b1\u20090.02. <jats:italic>T. caramanicus<\/jats:italic> Jalas essential oils were used to treat all bacteria, and the findings showed that <jats:italic>T. caramanicus<\/jats:italic> Jalas had a substantial inhibitory impact on the expression of <jats:italic>cagA<\/jats:italic>, <jats:italic>vacA<\/jats:italic>, and <jats:italic>babA2<\/jats:italic> virulence\u2010related genes (<jats:italic>p<\/jats:italic> &lt; 0.05). <jats:italic>Conclusions<\/jats:italic>. In a dose\u2010dependent manner, the EOs of <jats:italic>T. caramanicus<\/jats:italic> Jalas EO demonstrated a high degree of antimicrobial property against <jats:italic>H. pylori<\/jats:italic> bacteria. The most efficient EOs were those from <jats:italic>T. caramanicus<\/jats:italic> Jalas with relative concentrations of thymol and carvacrol, followed by the coumarin\u2010dominated pterygium EO with reduced antibacterial activity.<\/jats:p>","DOI":"10.1155\/2024\/3627074","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T04:49:09Z","timestamp":1717994949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010<i>Helicobacter pylori<\/i> Effects of <i>Thymus caramanicus<\/i> Jalas Essential Oils: A New Antimicrobial Approach"],"prefix":"10.1155","volume":"2024","author":[{"given":"Sepehr","family":"Asadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-2297","authenticated-orcid":false,"given":"Ebrahim","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-5456","authenticated-orcid":false,"given":"Amir","family":"Shakerian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/diseases9040066"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12054"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-016-0647-1"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/757941"},{"key":"e_1_2_10_5_2","first-page":"1","article-title":"Pylori infection and extra-gastroduodenal diseases","volume":"25","author":"Tsay F. 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