{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T11:50:03Z","timestamp":1759146603955,"version":"3.41.2"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"vor","delay-in-days":314,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> A nutritional supplement based on medicinal plants (saffron and ashwagandha), tryptophan, and vitamin B6 could contribute to alleviating\/improving mood and associated disorders. The aim of this study was to evaluate the potential benefits of this combination supplement. During the study period, participants underwent a period of forced home confinement due to the COVID\u201019 pandemic, which represented an unexpected impact factor.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This open\u2010label prospective trial enrolled a cohort of female employees who reported mild to moderate anxiety. The primary objective was to evaluate changes in the level of anxiety using the adapted Hamilton Anxiety Rating Scale (HARS) after 12 weeks of regular supplementation with Safromotive (two tablets daily, for 12 weeks). The secondary objectives were to evaluate health\u2010related quality of life (HRQoL) and tolerability.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In total, 46 women with a mean age of 45.0 (6.5) years were included. A statistically significant improvement in HARS was observed, with a 7.5\u2010unit decrease from baseline to 12 weeks (<jats:italic>p<\/jats:italic>\u2009 &lt; 0.0001) and from 4 to 12 weeks of supplement intake (<jats:italic>p<\/jats:italic> = 0.0058). However, no significant changes were found during the lockdown period (between weeks 8 and 12 of the study). No relationship was found between women\u2019s sociodemographic characteristics and the HARS total score. A significant reduction in the HRQoL questionnaire score of 1.2 units was observed between baselines and 12 weeks of treatment (<jats:italic>p<\/jats:italic> = 0.0273). At the end of the study, 78.6% of the women reported consistency the supplement intake during the study course.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This nutritional supplement composed of saffron, ashwagandha, tryptophan, and vitamin B6 appears to improve anxiety and HRQoL, but confinement could have impacted the evolution of the outcome.<\/jats:p>","DOI":"10.1155\/2024\/3661412","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T07:04:12Z","timestamp":1731308652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild\u2010to\u2010Moderate Anxiety During the COVID\u201019 Lockdown"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8508-5921","authenticated-orcid":false,"given":"Cristina","family":"Pages-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3420-4437","authenticated-orcid":false,"given":"M. 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