{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:25:14Z","timestamp":1781241914115,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100024491","name":"Fifth Third Bank","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012218","name":"John Hauck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Dengue fever (DF) is a mosquito\u2010borne illness with substantial economic and societal impact. Understanding laboratory trends of hospitalized Dominican Republic (DR) pediatric patients could help develop screening procedures in low\u2010resourced settings. We sought to describe laboratory findings over time in DR children with DF and DF severity from 2018 to 2020.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Clinical information was obtained prospectively from recruited children with DF. Complete blood count (CBC) laboratory measures were assessed across Days 1\u201310 of fever. Participants were classified as DF\u2010negative and DF\u2010positive and grouped by severity. We assessed associations of DF severity with demographics, clinical characteristics, and peripheral blood studies. Using linear mixed\u2010models, we assessed if hematologic values\/trajectories differed by DF status\/severity.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 597 of 1101 with a DF clinical diagnosis were serologically evaluated, and 574 (471 DF\u2010positive) met inclusion criteria. In DF, platelet count and hemoglobin were higher on earlier days of fever (<jats:italic>p<\/jats:italic> &lt;  = 0.0017). Eighty had severe DF. Severe DF risk was associated with thrombocytopenia, intraillness anemia, and leukocytosis, differing by fever day (<jats:italic>p<\/jats:italic> &lt;  = 0.001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In a pediatric hospitalized DR cohort, we found marked anemia in late stages of severe DF, unlike the typically seen hemoconcentration. These findings, paired with clinical symptom changes over time, may help guide risk\u2010stratified screenings for resource\u2010limited settings.<\/jats:p>","DOI":"10.1155\/2024\/3716786","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T10:34:13Z","timestamp":1722681253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Complete Blood Count Values Over Time in Young Children During the Dengue Virus Epidemic in the Dominican Republic From 2018 to 2020"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-0177","authenticated-orcid":false,"given":"Melissa E.","family":"Day","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-9940","authenticated-orcid":false,"given":"Yonairy Collado","family":"Puello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4581-1088","authenticated-orcid":false,"given":"Miguel E.","family":"Mej\u00eda Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0770-3967","authenticated-orcid":false,"given":"Elvira J.","family":"Diaz Brockmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F.","family":"D\u00edaz Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Rivera Defill\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla M.","family":"Taveras Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier O.","family":"Santiago P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Me\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-2996","authenticated-orcid":false,"given":"Ces\u00e1r","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-1682","authenticated-orcid":false,"given":"Margaret K.","family":"Hostetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Muglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Gonzalez","family":"del Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-4439","authenticated-orcid":false,"given":"Elizabeth P.","family":"Schlaudecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-9946","authenticated-orcid":false,"given":"Lisa J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8643-0161","authenticated-orcid":false,"given":"Brittany N.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-3531","authenticated-orcid":false,"given":"Carlos E.","family":"Prada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00026-8"},{"key":"e_1_2_11_3_2","volume-title":"Epidemiological update dengue","author":"Pan American Health Organization","year":"2020"},{"key":"e_1_2_11_4_2","volume-title":"Comprehensive guideline for prevention and control of dengue and dengue haemorrhagic fever","author":"World Health Organization","year":"2011"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02947-y"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-018-0116-1"},{"key":"e_1_2_11_7_2","volume-title":"Prevalence of anaemia in children aged 6\u201359 months (%)","author":"World Health Organization","year":"2019"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0440"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-022-00647-3"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piac136"},{"key":"e_1_2_11_11_2","volume-title":"Guidelines for diagnosis, treatment, prevention and control","author":"World Health Organization","year":"2009"},{"key":"e_1_2_11_12_2","first-page":"3","article-title":"Changing haematological parameters in dengue viral infections","volume":"24","author":"Jameel T.","year":"2012","journal-title":"Journal of Ayub Medical College Abbottabad"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1451-5"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2015.12.005"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004060"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2024.04.011"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2019.07.012"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(08)60435-3"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-106"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00146-8"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/3716786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T10:34:21Z","timestamp":1722681261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/3716786"}},"subtitle":[],"editor":[{"given":"Christina","family":"Pabelick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/3716786"],"URL":"https:\/\/doi.org\/10.1155\/2024\/3716786","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3716786"}}