{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:02:43Z","timestamp":1740164563593,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015822","name":"Fondazione Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:p>Inflammatory bowel diseases (IBD), including Crohn\u2019s disease and ulcerative colitis, are lifelong conditions with no definite cure. Several studies demonstrated that patients with IBD more frequently experience symptoms of common mental disorders, such as anxiety and depression, because of bidirectional communication through the gut-brain axis and the chronicity of symptoms, as well as because of impaired quality of life and reduced social functioning. However, psychological conditions of affected patients are often underestimated and not fully considered. Herein, we present the case of a 37-year-old woman with Crohn\u2019s disease and a mild depressive condition, characterized by anxious distress, tachycardia, tachypnea, tremors, sweating, avoidant behaviors, and intestinal somatizations (diarrhea), who was treated with Pregabalin upon indication of the referring psychiatrist. Following the beginning of the treatment, the patient rapidly reported an improvement in the overall clinical symptoms as well as a better management of psychic and physical anxiety with a marked reduction in diarrheal discharges under stress at work. After 6 months of Pregabalin therapy, we additionally observed an improvement in Crohn\u2019s disease activity, both clinically, in the laboratory, and endoscopically. Our case showed that patients with Crohn\u2019s disease and anxiety problems may benefit from low-dose Pregabalin medication to improve both their mental and physical condition.<\/jats:p>","DOI":"10.1155\/2024\/3744500","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T21:20:08Z","timestamp":1710537608000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Low Dose Pregabalin Improves Gastrointestinal Symptoms of Crohn\u2019s Disease"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6807-5796","authenticated-orcid":true,"given":"Antonio Maria","family":"D\u2019Onofrio","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Section of Psychiatry, Universit\u00e0 Cattolica del Sacro Cuore, Rome 00168, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-7641","authenticated-orcid":true,"given":"Federica","family":"Di Vincenzo","sequence":"additional","affiliation":[{"name":"UOS Malattie Infiammatorie Croniche Intestinali, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, Rome 00168, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7134-7524","authenticated-orcid":true,"given":"Gaspare Filippo","family":"Ferrajoli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Section of Psychiatry, Universit\u00e0 Cattolica del Sacro Cuore, Rome 00168, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-7541","authenticated-orcid":true,"given":"Franco","family":"Scaldaferri","sequence":"additional","affiliation":[{"name":"UOS Malattie Infiammatorie Croniche Intestinali, CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario \u201cA. 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