{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:58:44Z","timestamp":1787061524523,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity in a rat model following a high\u2010fat\u2010sugar diet (HFSD).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    The MPT was prepared through the customary method of decoction and was subjected to analysis for its polyphenol composition using reversed\u2010phase high\u2010performance liquid chromatography (RP\u2010HPLC). Two specific doses of MPT, namely, 250 and 500\u2009mg\/kg body weight (BW), were chosen for the study\u2014referred to as MPT\u2010250 and MPT\u2010500, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Result:<\/jats:bold>\n                    The main phenolic acids and flavonoids identified in MPT, with concentrations exceeding 10\u2009mg\/100\u2009mL of tea, included catechin, rutin, salicylic acid, gallic acid, sinapic acid, chlorogenic acid, cinnamic acid, and ellagic acid. The total phenolic (TP) and total flavonoid (TF) contents in MPT were measured to be 5.53 and 7.73\u2009mg\/g, respectively. Additionally, MPT demonstrated a 57.2% scavenging capacity with 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl radical. Notably, the administration of a higher dose (MPT\u2010500) showed a significant reduction in body mass index (BMI) and a 51.24% reduction in the rate of increase in BW compared to the HFSD group. The findings indicated that all the treatment groups, that is, orlistat treatment (OT), MPT\u2010250, and MPT\u2010500 groups, experienced reduced levels of serum total cholesterol (TC), triglyceride (TG), and markers of lipoproteins in contrast to the HFSD group. Moreover, MPT helped restore the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH), thereby demonstrating its potential in combating oxidative stress. The MPT\u2010500 group also displayed decreased liver and kidney weights and an improved atherogenic index when compared to the HFSD group.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The results clearly indicate that a high dosage of MPT showed antiobesity activity which was comparable to the same effects produced by the conventional drug orlistat.\n                  <\/jats:p>","DOI":"10.1155\/2024\/3833521","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T05:50:57Z","timestamp":1728021057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Bioprotective Effects of Marigold Tea Polyphenols on Obesity and Oxidative Stress Biomarkers in High\u2010Fat\u2010Sugar Diet\u2010Fed 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