{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:46:19Z","timestamp":1778154379954,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":298,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> No consensus has been reached on the adequate dose of mitomycin C (MMC) in XEN45 gel stent implantation. Lower doses have the potential to reduce MMC\u2010linked side effects. This study aimed to evaluate treatment efficacy of ab interno XEN45 gel stent in primary open\u2010angle glaucoma (POAG) with three different MMC doses.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This retrospective single\u2010centre nonrandomised trail included 54 patients (56 eyes) who underwent XEN45 gel stent implantation for POAG with above\u2010target intraocular pressure (IOP) under medical therapy. Eyes were grouped according to the received MMC dose: Group 1 (20\u2009<jats:italic>\u03bc<\/jats:italic>g; <jats:italic>n<\/jats:italic>\u2009=\u200921), Group 2 (10\u2009<jats:italic>\u03bc<\/jats:italic>g; <jats:italic>n<\/jats:italic>\u2009=\u200914) and Group 3 (5\u2009<jats:italic>\u03bc<\/jats:italic>g; <jats:italic>n<\/jats:italic>\u2009=\u200921). The primary endpoint was the mean IOP change in the three MMC dose groups after 6, 12 and 24\u2009months. Secondary endpoints included the success rate defined as lowering of baseline IOP \u2265 20% and below a cut\u2010off IOP set at three different levels: \u2264 18, \u2264 16 and \u2264 14\u2009mmHg (Criteriums 1, 2 and 3), the mean number of ocular hypotensive medications and the frequency of needling procedures.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After 24\u2009months, the overall mean (standard error) IOP was significantly reduced from 24.7 (0.9) mmHg to 15.2 (0.7) mmHg (<jats:italic>p<\/jats:italic> &lt; 0.0001). The average IOP change (standard error) in MMC dose groups 1, 2 and 3 was \u22128.6 (2) mmHg, \u221210.1 (2.1) mmHg and \u221210.4 (2.8) mmHg. Complete success (Criterium 1) was achieved in 50%, 62% and 43% of the eyes in groups 1, 2 and 3. No statistically significant difference was found within the first 24\u2009months between the three MMC dose groups for IOP change, success rate, number of ocular hypotensive medications and the frequency of needling procedures.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> XE45 was effective in all three dose groups. As the success rate did not significantly differ between the MMC doses, these results may support the use of the lowest dose.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> ClinicalTrials.gov identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/559\/2016BO2\">559\/2016BO2<\/jats:ext-link><\/jats:p>","DOI":"10.1155\/2024\/3895054","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T06:24:32Z","timestamp":1729923872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Results of XEN45 Gel Stent Implantation in the Treatment of Primary Open\u2010Angle Glaucoma Using 5, 10 or 20\u2009<i>\u03bc<\/i>g Mitomycin C: A Pilot Study"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9325-5616","authenticated-orcid":false,"given":"Felix F.","family":"Reichel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Guggenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-7264","authenticated-orcid":false,"given":"Hanna","family":"Faber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4120-534X","authenticated-orcid":false,"given":"Jonas","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-126X","authenticated-orcid":false,"given":"Bogomil","family":"Voykov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200404000-00008"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.10.026"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/vision7030054"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.01.032"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5457246"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.004"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3895-3"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.07.023"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000000858"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-3899-7"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000000352"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16625"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2021.1934035"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01764-8"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(14)72903-4"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.6.586"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(00)00085-3"},{"key":"e_1_2_11_18_2","first-page":"88","article-title":"The Cytotoxic Effect of Topical Mitomycin C on the Ciliary Body in Rabbits","volume":"102","author":"Hara T.","year":"1998","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199610000-00007"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2018.04.301"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.3.297"},{"key":"e_1_2_11_22_2","first-page":"15","article-title":"Consensus on Definitions of Success","author":"Heuer D.","year":"2009","journal-title":"Guidelines on Design and reporting of Glaucoma Surgical Trials"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1999.0816"},{"key":"e_1_2_11_24_2","first-page":"449","article-title":"Antimetabolite-Induced Apoptosis in Tenon\u2019s Capsule Fibroblasts","volume":"39","author":"Crowston J. 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