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CD4+ T cells are the mainstay of the body\u2019s immune system, and the depletion of CD4+ T cells in sepsis is of great concern. Cytotoxic T lymphocyte\u2010associated protein 4 (CTLA4) is a negative immunomodulator for T cell activation and degradation through the autophagy\u2010lysosome pathway. Mammalian target of rapamycin (mTOR) is the most classical upstream regulator of autophagy. With a mouse model of sepsis through cecal ligation and puncture (CLP), T cell specific\u2010mTOR\/tuberous sclerosis complex 1 (TSC1)\u2010knockout mice, and bafilomycin A1, a specific autophagosome\u2010lysosome (A\u2010L) fusion inhibitor, we primarily proved that mTOR could modulate the expression and accumulation of CTLA4 by regulating the onset process of autophagy such as A\u2010L fusion. Given such a regulatory relationship, targeting mTOR could provide new light to improve immune function in sepsis, and the prospect of using rapamycin in the clinic would be worth exploring further.<\/jats:p>","DOI":"10.1155\/2024\/4233439","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T11:50:33Z","timestamp":1721908233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["mTOR Deletion Alleviates CD4+ T\u2010Cell Dysfunction in Sepsis through Reducing CTLA4 Accumulation Mediated by Rescuing Autophagy"],"prefix":"10.1155","volume":"2024","author":[{"given":"Xianli","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-9228","authenticated-orcid":false,"given":"Na","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5085-0"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3552"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01364"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065x.1996.tb00919.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.3.561"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7888"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182168cce"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc12711"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5371"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.113"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902664"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.43507"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73939"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-022-01719-y"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-022-01740-1"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.214"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1066957"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4100"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc11404"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.01.035"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106221"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2476"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.03.005"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03255.x"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0639-8"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni969"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.069"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2300060"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01289-w"},{"key":"e_1_2_9_30_2","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-03961-9","article-title":"Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury","volume":"12","author":"Liu Q.","year":"2021","journal-title":"Cell Death & Disease"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14305"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26824-5"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316388"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0449-x"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13326"},{"key":"e_1_2_9_36_2","doi-asserted-by":"crossref","unstructured":"YuanW. 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