{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:05:33Z","timestamp":1791932733907,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019562","name":"Instytut Botaniki, Uniwersytet Jagiello\u0144ski","doi-asserted-by":"publisher","award":["N41\/DBS\/001186"],"award-info":[{"award-number":["N41\/DBS\/001186"]}],"id":[{"id":"10.13039\/501100019562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To characterize the eosinophilic granulomatosis with polyangiitis (EGPA) population from the POLVAS registry depending on ANCA status and diagnosis onset, including their comparison with the granulomatosis with polyangiitis (GPA) subset with elevated blood eosinophilia (min. 400\/\n                    <jats:italic>\u03bc<\/jats:italic>\n                    l) (GPA HE) to develop a differentiating strategy.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A retrospective analysis of the POLVAS registry.\n                    <jats:italic>Results<\/jats:italic>\n                    . The EGPA group comprised 111 patients. The ANCA\u2010positive subset (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200945 [40.54%]) did not differ from the ANCA\u2010negative one in clinics. Nevertheless, cardiovascular manifestations were more common in ANCA\u2010negative patients than in those with anti\u2010myeloperoxidase (MPO) antibodies (46.97% vs. 26.92%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.045). Patients diagnosed before 2012 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200970 [63.06%]) were younger (median 41 vs. 49 years,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.01), had higher blood eosinophilia at diagnosis (median 4,946 vs. 3,200\/\n                    <jats:italic>\u03bc<\/jats:italic>\n                    l,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.01), and more often ear\/nose\/throat (ENT) and cardiovascular involvement. GPA HE comprised 42 (13.00%) out of 323\u2009GPA cases with reported blood eosinophil count. Both GPA subsets had a lower prevalence of respiratory, cardiovascular, and neurologic manifestations but more often renal and ocular involvement than EGPA. EGPA also had cutaneous and gastrointestinal signs more often than GPA with normal blood eosinophilia (GPA NE) but not GPA HE. The model differentiating EGPA from GPA HE, using ANCA status and clinical manifestations, had an AUC of 0.92, sensitivity of 96%, and specificity of 95%.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Cardiovascular symptoms were more prevalent in the ANCA\u2010negative subset than in the MPO\u2010ANCA\u2010positive one. Since EGPA and GPE HE share similarities in clinics, diagnostic misleading may result in an inappropriate therapeutic approach. Further studies are needed to optimize their differentiation and tailored therapy, including biologics.\n                  <\/jats:p>","DOI":"10.1155\/2024\/4283928","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T15:05:07Z","timestamp":1714057507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS 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